Side effects with omeprazole/Prilosec use

The body aches are my arms and legs primarily ; also some nausea as well. Also seems to increase anxiety which I see is mentioned online

@jmedj55 - From my own experiences in recent years, I am now a believer that medications can have really pronounced side effects for some, while other patients experience none.

I took an entirely different medication than the omeprazole (Prilosec) you mentioned, semaglutide (Wegovy), which my husband took, as well. I had such bad gastrointestinal side effects I had to finally talk to my doctor about a new medication. At the same time, my husband had zero side effects. I also experienced a side effect where I felt like I had drunk far too much alcohol after taking a medication a dermatologist prescribed, and it took 12 hours to recover. It turns out that was a reported, but really unusual side effect.

Here is an article on the topic of varying side effects for different patients I found useful:

- Why Prescription Drugs Can Work Differently for Different People https://today.uconn.edu/2021/10/why-prescription-drugs-can-work-differently-for-different-people-2/

I had a terrible time with this. I was on a PPI and an H2 blocker. I started weaning from the PPI by taking it every other day and not reducing the H2b. Then every third day, 4th day until off. Then same with H2 blocker. The first week the rebound reflux from the PPI was noticeable and I used some gaviscon when it was really bad. No issues weaning from the H2b. Best of luck!!!

I took Omeprazole for 2 years for GERD and it seemed to be helping a lot. Then day I woke up and my left leg was swollen. After many doctors and loads of tests, I happened to read in a NIH report that Omeprazole sometimes exacerbated arthritis in your joints. Since I have arthritis in my left hip, I went to my Gastro and asked to get off Om. He said he'd never heard of that reaction and RELUCTANTLY put me on Pepcid. Within 48 hours, my leg was back to normal and the Pepcid is handling the GERD just fine.

Ditto. Proton pump inhibitors like Nexium and Prilosec are
Triggers for a condition called Microscopic colitis - an awful, I’ll do anything to stop it kind of thing.

So
I too transitioned to Pepcid. I had to supplement with an additional one mid afternoon for a few days and then Tums - but now it’s all good.

I was on Pantoprozole, which is similar, and I weaned myself off. Instead of one pill a day, I took one pill every other day and finally stopped.

PPIs also create a favorable environment for helicobacter pylori to thrive. ( causes ulcers)

I am trying to wean off Nexium. Down to every 4 days 20 mg. No issues so far. Wonder if I ever had Gerd. Weird. But it’s caused me to have bleeding stomach
Polyps that are quite large.

I have Osteoporosis. I take Osteoporosis meds and bhrt. Because of my acid reflux I was prescribed Omeprazole. When I read that it can inhibit calcium absorbtion I was concerned. Since then I have resumed the ppi and am not going to worry about the calcium issue. At 77 I am refusing to worry about the myriad issues with medication side effects. My life is too short. I

Hi, I was diagnosed with esophagitis / silent gerd and put on pantoprazole for a few months. When I tried to stop the pantoprazole I had severe heartburn. (I never actually had heartburn before I started the PPI). After ~1 month of torture, I went back on the PPI, but to a half dose. I took half dose for about a month and then alternated that with famotidine until I switched, then started weaning off famotidine. My real question for this group is…is it worse to be on a PPI daily long term or to be on famotidine daily long term or are they equally bad for both osteoporosis and dementia? Does anyone have any insight on this? Thanks