Now on 3 wks with Kevzara shot and now no prednisone. Just fatigue.

I experienced extreme fatigue when stopping the prednisone. It seemed to take 5-6 months to feel better. I did not take Kevzara. My PMR had went to remission. I am not sure how long you were on prednisone and when you stopped but prednisone in itself can cause the problem. I think we have overworked our cortisol system and it just takes awhile to restart to your daily needs.

Like tuckerp says, the fatigue could be from tapering off of prednisone, but it could also be due to your PMR not being full controlled. Since you are spacing your injections out, the level of Kevzara in your body goes down. It could be that the level has dropped below the level needed to control your PMR. If the fatigue continues you should discuss it with your doctor.

@jeff9 i thought that fatigue was a symptom of withdrawal symptoms, not pmr flare.?

I just checked Google AI, and here is what it said about fatigue from switching Kevzara injections from 2 to 3 weeks:

Potential Causes of Fatigue
- Subtherapeutic Drug Levels: The standard, studied dose for PMR is 200 mg every 2 weeks. Extending the interval to 3 weeks may drop the medicine level in your body too low to fully suppress the inflammatory proteins (IL-6) that cause systemic exhaustion.
- Early PMR Flare: Fatigue is often one of the very first warning signs of a breakthrough PMR flare, frequently arriving before or alongside stiffness and pain in the shoulders, neck, or hips.
- Steroid Taper Interaction: If you are simultaneously reducing your corticosteroid (prednisone) dose, your adrenal glands may also be struggling to catch up with cortisol production, compounding the wear-off fatigue.

@jeff97

I have been off prednisone since May 3rd (2026) and I haven’t had pain or stiffness since mid April (2026). Intermittent but significant fatigue is my only symptom since switching to 3 wk Kevzara injection.
John