New research on length of ADT therapy for patients with RT

Posted by ededed @ededed, Dec 11, 2025

Interesting article !!! What I got out of it is that if you take ADT longer than 12 months you may be less likely to die from prostate cancer and more likely to die from other causes. Oh joy !

Here's the article
Original Investigation:
Optimal Duration of Androgen Deprivation Therapy With Definitive Radiotherapy for Localized Prostate Cancer
A Meta-Analysis
https://jamanetwork.com/journals/jamaoncology/article-abstract/2841671

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

Profile picture for heavyphil @heavyphil

@wheel1 Yes, no one is denying these side effects - certainly not me.
But when faced with a serious cancer diagnosis - ie; serious as in possibly fatal - I don’t think you can afford NOT to gain as much advantage as possible.
Yes, there are some men on this board who have experienced hell and continue to do so ..,but they are vastly LESS in number than those of us who have tolerated the SE’s and completed treatment successfully.
Do I feel badly for those men who have suffered? Absolutely! I wish nothing but the best for all who have to deal with this.
But I would remind everyone that if a drug or treatment helps 90% of the people who take it, and harms 10%, that there is a fantastic drug or treatment. Should the 90% simply languish, not be afforded the treatment or…what???
I was told all the risks of ADT right up front by my RO and his NP; I read about them extensively as well.
Was I afraid to take Orgovyx because of the possible SE’s? NOPE, because dying from the prostate cancer scared me a hell of a lot more!!
I totally get the ‘buyer’s remorse’ if someone disregarded the possible negative outcomes - or worse, was cajoled into going on ADT, but let’s not paint a picture of doom and gloom.
There are others out there with different, less treatable cancers who only WISH they had something like ADT to halt progression in its tracks. Best,
Phil

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@heavyphil Good points. Keeping things in perspective the people on these types of medical websites are mostly trying to learn about their medical condition or looking for help with side effects, etc etc. But there are many more that treat without any major problems and have no need to visit these forums.

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