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New research on length of ADT therapy for patients with RT

Posted by ededed @ededed, Dec 11, 2025

Interesting article !!! What I got out of it is that if you take ADT longer than 12 months you may be less likely to die from prostate cancer and more likely to die from other causes. Oh joy !

Here's the article
Original Investigation:
Optimal Duration of Androgen Deprivation Therapy With Definitive Radiotherapy for Localized Prostate Cancer
A Meta-Analysis
https://jamanetwork.com/journals/jamaoncology/article-abstract/2841671

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ededed | @ededed | 10 hours ago
In reply to @northoftheborder "@ededed (Late reply) Yes, monitoring closely. Right now, whatever the article speculates, we don't have phase..." + (show)
Profile picture for northoftheborder @northoftheborder

@ededed (Late reply) Yes, monitoring closely. Right now, whatever the article speculates, we don't have phase 3 trials showing that it's safe to go off ADT with stage 4, but they're underway. In my case, the LIBERTAS trial covers *exactly* my situation: stage-4 castrate-sensitive prostate cancer being treated with ADT and Erleada (Apalutamide). We should have preliminary results this fall. Small-scale retrospective studies and "may be optimal" are intriguing, but I need a little more than that before making a potentially life-threatening decision. I very much hope that the article you shared ends up being validated in full trials.

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@northoftheborder For me it was a quality of life decision. Walking up a flight of stairs was difficult and painful from my ADT. Yes, our decisions on this pc road can have devastating results or lead us to a better tomorrow. I recognize that each decision whether it is ours or our trusted physicians has potential costs and hopefully benefits.

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