New medication Dupiexnt just approved Sept.

Congratulations, that's great news for you. Happy that you're already seeing such positive results.
I was recently approved to start the Dupixent as well and had my first injection last week. I haven't had the dramatic positive effects that you describe, but have noticed I've had a little less frequent need for my inhalers. I am on Breztri as well along with Combivent-Respimat as a rescue inhaler.
Your positive story certainly gives me hope! I'm remaining optimistic and patient. Looking forward to see how others respond to this as well.

Good morning Donna. I did so much research looking for new treatments for COPD. When I ran across the Dupiexnt I was thinking this is may be my last option. I compared what the medicine does to my lab results. The medicine targets eosinophil. This is a white blood cell that causes inflammation which happens with allergies. I looked on my patient portal and looked at my CBC blood test results and sure enough my eosinophil white cell count was high meaning there was something causing an allergic reaction which caused the inflammation in my lungs or airway. I'm just grateful I found this information and hope that it can help someone else. Maybe when you go back to your doctor ask him is your eosinophil white blood cell count high. If it is then you know you are on the right track. Good luck and keep me posted on your progress.

Good morning, Yes, my eosinophil count has been high for sometime and my latest CT showed significant inflammation in my lungs and airway. My pulmonologist referred me to an immunologist/allergist. She is the one who started me on the Dupixent and has now officially diagnosed me with eosinophilia.
I applaud your research, I'm the same way. I've learned that we must be our own best healthcare advocate, that's rule #1 for me.
I have a great team of doctors and am grateful for that.
Thank you for sharing and reaching out!

I started on Dupixent last November (2023) and was greatly impressed until May 2024. It seemed though it just switched off for some reason and had 4 exacerbation between may and August.
Now I understand that there is a new medication by Verona Pharm by the name of Ohtuvayre that is available to COPD patients. It is administered via jet-nebulizer twice a day. Has anyone started on this or discussed it with their Pulmolologist?

Hello I see you started you Dupiexnt last year in November but it was not approved by the FDA for COPD at that time. It was used for eczema and nasal polyp. You might want to check to see if the medication has been upgraded for COPD. I can't believe a Dr gave you the medicine for COPD when it was not approved for that. Did your insurance pay for it. It was just approved September 2024 for COPD. You can Google it

Hello again I was just reading this. Maybe you was in a clinical trial when you got the Dupiexnt. As of late 2023, people with COPD who are taking Dupixent are primarily those participating in clinical trials, as Dupixent was recently approved by the FDA for the treatment of COPD, making it the first biologic medication specifically indicated for the disease; this means access to Dupixent for COPD is likely limited to individuals enrolled in clinical studies or those who can access it through early access programs following its approval.

That is no correct. As we all know medicine is not a cut and dry science......there were many criteria one had to meet other that just a Dx of COPD, and also there was consideration of exacerbation requiring Steroids, and also Eosinophil count both in blood and sputum. It is difficult to explain to people that don't work in the medical arena that there are numerous times medications are prescribed for what is called "off-label" use. In fact if you research it almost 20% of prescriptions written are for off-label use. As of July, Dupixent has been approved through the FDA for COPD patients....Dupixent has about 7 indicators that it is used for. So to date, the two new drugs that have been approved just this summer by the FDA for COPD (specifically and not off-label) are Dupixent and Ohtuvayre.

Yes I read that before it was approved for COPD that is was already approved for Asthma so they could prescribed it for breathing problems. I am sorry it just stopped working for you. Are you still taking it and how is your Eosinophil level running now. I do hope you can find something to help you. I hope this Dupiexnt keeps helping me or I don't know what I'm going to do 😔.

I was prescribed Dupixent and will start taking it at the end of next month, after I’m done traveling for the year. (I didn’t want to bring it along on my trips and have to be concerned with starting a new Rx while traveling (especially one that should be kept under 77 degrees.

I have asthma and copd and high eosinophils. I also have 1-6 exacerbations/year and we hope this will help them be less frequent and less severe.

Hello I think waiting until your travel is over before starting is a good idea. You don't know if you will have any type of reaction to it. I was worried with my first injection. I believe I made my own self anxious for no reason because I didn't have any side effects from the first injection. My next injection will be next week. I have not had to use my emergency inhaler since I've started. I just use my maintenance Breztri twice a day. I am breathing so much better. I hope you will have good response as well .