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Glioblastoma: Anyone have difficulty walking, use of legs and arms?
My husband was diagnosed with Glioblastoma last August, affecting both hemispheres of his brain. He underwent surgery to remove 90% of the cancerous cells from a 5cm section in his right brain. The cancerous cells in his left brain were smaller, but due to their location being too deep, surgery was not possible. He subsequently underwent radiotherapy and chemotherapy. Later, due to cerebral edema, his right leg and right hand became completely weak, he had difficulty maintaining his balance, walking became extremely difficult, and he became very weak, constantly tired and sleepy. Therefore, his chemotherapy was paused for almost three months. His doctor prescribed dexamethasone, currently 6mg daily, and he has also undergone two Mvasi infusions, but there has been no improvement. He still has difficulty walking with his right leg and cannot use his right hand. Has anyone experienced similar problems? What methods can help improve his condition? Is this common issue to Glioblastoma patient? Thank you for any suggestions.
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My husband, Jeff was diagnosed with Grade 4 glioblastoma (GBM), IDH-wildtype and MGMT-unmethylated, in December 2025. His diagnosis was discovered after he suffered a grand mal seizure on December 21, 2025. Before this, he was extremely active and fit.
Because he continued having seizures, he had to be placed in a medically induced coma. He woke up on December 25, 2025, and remained hospitalized until January 13, 2026. During that 24-day hospitalization, he spent 11 days in the ICU.
As a result of the tumor and seizures, his left side was significantly weakened, affecting his mobility and balance. His short-term memory, vision, and cognitive abilities were also impacted. But through 7 weeks of physical and occupational therapy, along with 5 weeks of cognitive therapy, he has made remarkable progress. He is now stronger, his movement and mobility have improved, and his short-term memory is getting better.
He completed 30 sessions of chemotherapy (TMZ) and radiation on April 8, 2026. We will be going to the Mayo Clinic to pursue further treatment, and he is expected to begin Optune Gio with TMZ in May. I am also currently communicating with two clinical trials and praying he qualifies.
At this time, he is on two anti-seizure medications, blood thinners for his DVT, and also has pain medication and Zofran for nausea, which works quickly. His oncologist has advised that the side effects from chemotherapy and radiation should begin to subside within a couple of weeks.
He is also following a low-carb, high-fiber, high-protein diet to support his healing. One of the greatest blessings during this journey has been our nightly prayer group. It has helped strengthen his positivity, deepen his faith, and draw him into a stronger relationship with God. His outlook on life has become more hopeful, positive, and truly inspiring.
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2 ReactionsThank you for sharing; it has been a great encouragement to me. Seeing your husband's remarkable progress from such a dire situation is truly inspiring and gives me renewed hope.
My husband's condition was relatively good before, except for the right side of his body. However, he recently suffered a minor stroke, leaving him unable to swallow or speak. Drinking and eating became difficult, and his appetite was poor. But thank God, recently his swallowing has shown miraculous improvement. His eating, drinking, and appetite have all greatly improved.
We also have a prayer group with nearly 150 people who regularly pray for him, which deeply moves and fills us with gratitude. My husband only underwent six weeks of radiotherapy and two rounds of chemotherapy before stopping due to weakness. He has been off chemotherapy for four months now, and we don't know when he can resume. But thank God, his tumor has not grown or recurred. We pray that God will continue to have mercy and protect him, stabilizing his condition and restoring his strength.