Ca25-29 and CA 15-3: One marker going up and the other down?

Posted by shireen71 @shireen71, Mar 29 10:38am

I was diagnosed with breast cancer ER positive her two negative. I was cancer free for four years and then I developed cancer in my liver MBC I am currently on Anastrozole and Virginio treatment initially my tumor marker CA 25–29 was 230 after my first treatment the markers went down to 48 and now the second month of treatment. My markers went up to 113 however, my CA 15 three markers was 118 before treatment and first month of treatment it went down to 98 second month treatment it went down to 60 my question is what does it mean when one marker goes goes down and the other one goes up after the second month of treatment

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Hello @shireen71 and welcome to Mayo connect. These numbers cause so much distress, I am sorry for that. They do tend to fluctuate, my doctor does not even test them regularly anymore. He says they aren’t really reliable enough to be helpful.
There is another conversation here on connect about this topic, from about a year ago. Here is a link,
https://connect.mayoclinic.org/discussion/ca-15-3-cancer-tumor-marker/
Being MBC is a hard label to come to terms with, I hope you don’t focus too much on the numbers. They can really make me crazy when I do that.
How are you doing now? Have you visited any of the other discussions yet?

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I am feeling ok, if it wasn’t for the blood test would have never known.
I just started to read about it, it’s alit to take in looking to see if anyone is in verzenio and for how long have they been on it and if it’s still working . I’m just afraid once it stop s working will the cancer grow fast .

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@shireen71

I am feeling ok, if it wasn’t for the blood test would have never known.
I just started to read about it, it’s alit to take in looking to see if anyone is in verzenio and for how long have they been on it and if it’s still working . I’m just afraid once it stop s working will the cancer grow fast .

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God bless you!

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Hello @shireen71 ,
I was diagnosed de novo ER/PR+, HER2 low lobular MBC in January 2022. I started Verzenio + Anastrozole in February. I have mets to bones. My CA markers turned to normal range after I started the meds and stayed liked that. After 18 months, my bone scans showed new sites on bones (mild progression). I wanted to continue for another 3 months and see what would happen. The next scans showed clear progression. All this time my markers were still under the normal limit. Then I was moved to Kisqali and Faslodex. My numbers rose after the first cycle, but then went back down in the second cycle. As a note, I had a liquid biopsy after progression which did not show anything.
My onco follows the CA markers but the main focus is on the scans. Even if the scan shows a progression (bones can be a bit more difficult to read), make sure you combine it with how you feel and other test results. If you feel like there's a conflict, ask for a re-read of the scans.
So, in my case CA markers and the progression was not quite correlated. For some people, the markers clearly go up before a scan shows a clear progression. You will probably see how it works for you.

I hope your line of treatment works great for you with minimal side effects.

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@eku

Hello @shireen71 ,
I was diagnosed de novo ER/PR+, HER2 low lobular MBC in January 2022. I started Verzenio + Anastrozole in February. I have mets to bones. My CA markers turned to normal range after I started the meds and stayed liked that. After 18 months, my bone scans showed new sites on bones (mild progression). I wanted to continue for another 3 months and see what would happen. The next scans showed clear progression. All this time my markers were still under the normal limit. Then I was moved to Kisqali and Faslodex. My numbers rose after the first cycle, but then went back down in the second cycle. As a note, I had a liquid biopsy after progression which did not show anything.
My onco follows the CA markers but the main focus is on the scans. Even if the scan shows a progression (bones can be a bit more difficult to read), make sure you combine it with how you feel and other test results. If you feel like there's a conflict, ask for a re-read of the scans.
So, in my case CA markers and the progression was not quite correlated. For some people, the markers clearly go up before a scan shows a clear progression. You will probably see how it works for you.

I hope your line of treatment works great for you with minimal side effects.

Jump to this post

Thank you so much this really helps alor, I’m getting my scans in may which would be 3 months on this 1st line of treatment. Wishing you complete recovery God Bless you

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@shireen71

I am feeling ok, if it wasn’t for the blood test would have never known.
I just started to read about it, it’s alit to take in looking to see if anyone is in verzenio and for how long have they been on it and if it’s still working . I’m just afraid once it stop s working will the cancer grow fast .

Jump to this post

I was on the Verzenio for three years. After the 3 year my tumor started going up. My oncologist have me on Orserdu and Kisqali. My tumor levels have started to ho down again🙏🏾

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