Mouth sores and Daraxonrasib

My husband was on Daraxonrasib for 3 weeks and had face rashes and mouth sores. We did all the things that was recommended and they would not clear up. The doctor took him off Daraxonrasib for one week and the mouth sores and face rashes cleared up in about 5 days. They then lowered him Daraxonrasib from 300 mgs to 200 mg. He also started taking Daraxonrasib at night. It's only been 2 days, but so far so good.

@katereese0820 I am glad that the break helped. Hopefully, the reduced dose will minimize the side effects. Please keep us posted. Everyone is learning from each other. Thanks.

I would have his daraxonrasib team know about the sores now, particularly if they are painful or interfering with eating or drinking. They can determine the severity and may prescribe a medicated mouth rinse or other treatment. They may change the dose. I have a friend that did that and it cleared up.

Many thanks for your reply’s to my question. Our oncologist has reduced my husbands dose to 200 and the NP estimated that about half her patients are currently on this reduced dose due to side effects.

@mariannefw That's a good thing. I hope it minimizes the side effects. Please let us know, if anything changes with the reduced dose? Thanks.

@katereese0820 taking the pill at night also helped my mom. She never got the mouth sores but had the rash and followed the preventative protocol She is also on a reduced dose of 200 mg and that seems to have done the trick. No more rash. I hope your husband continues to do well on the reduced dose.