ANA positive with Mitotic Spindle Fibers

Posted by wnyprincess83 @wnyprincess83, Apr 2 9:21am

I recently tested positive for ANA with a Titer of 1:4 and a pattern on Mitotic Spindle Fibers. We ordered more bloodwork for SLE, Sjorgren's, Celiac, and RA. The SLE and Sjorgren's have came back fine so far. And I have no symptoms of the other 2 so I'm not too worried about that. But what other conditions can be caused by this cell pattern?

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I have recently been diagnosed ANA positive with a pattern of Mitotic Spindle Fibers. So far I've tested negative for SLE, RA, Sjorgens, and Celiacs. What other conditions could there be?


@wnyprincess83. Does your name mean what I think it means? Whiny princess? That fits me to a T. I always feel like I’m whining about my autoimmune disease. But that’s another story! Welcome to Mayo Clinic Connect! Everyone here is very helpful and supportive and we will do our best.
To be honest, I don’t understand all the lab values you mentioned. We’re all volunteers who share our health journeys and don’t get into labs.
Can you tell me what symptoms made you go to the doctor and have the bloodwork done? And what has the doctor said about the results of your tests?


Haha no. I live in Western New York.

My doctor hasn't decided next course yet. She ordered the ANA because I am getting blood spots on my skin, I have sores on my scalp, terrible back pain, inflammation in neck, shoulders, and chest cavity. I have trouble standing and walking up and down stairs and pain when I put my arms up. I had some elevated blood work as well. Once the ANA came back positive, with that cell pattern, she check the common causes. But those are normal


I'd like to invite @glasslynne, @aljordan, and @mekahna to this discussion to share their experiences with mitotic spindle fibers and a positive ANA test.


So my doctor going to send me to a rheumatologist.


That’s good news. Many autoimmune disorders have symptoms precede lab evidence by months or years, which makes diagnosis difficult and delayed. A skin biopsy with immune fluorescent studies of the scalp lesions is probably the quickest and easiest way to get a diagnosis or clues to follow. The immune fluorescent studies are essential so please ask the dermatologist to include those in view of your positive ANA. It’s done with a local anesthetic and is tiny. You might discuss this with your PCP especially if you need a referral. I hope you get answers soon since you’re clearly having symptoms that could be consistent with an autoimmune disorder. Please keep us posted on your progress.

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