MGUS and Non-Hematologic Malignancy

I have nothing to add. Just thanking you for this information. My husband was diagnosed with MGUS a couple of years back. I'm a nervous wreck.

@dmdinapoli81
https://pmc.ncbi.nlm.nih.gov/articles/PMC9096784/
I have posted a link that I thought was interesting showing a possible link of MGUS to infections, autoimmunity and inflammation. Here is my opinion. When the body is under constant inflammation due to whatever source, disease can set in. I had Inguinal hernia surgery in 2017 with a mesh patch and have had recurring pain in that area since. I consulted a surgeon since who stated that the body recognizes the mesh patch as foreign and forms scar tissue around it. Some people’s immune system react to this foreign material (remember the issues with silicone breast implants?) and constant inflammation sets in. My MGUS was diagnosed in 2021 although I knew something was amiss in my body 2-3 years prior to that. So I believe we need to do everything we can in regard to diet, exercise, sleep and healthy living (no sugar, smoking, alcohol, processed foods etc) to alleviate inflammation in our bodies especially as we age because our detoxification system doesn’t work as well. I decided to go ahead with a bone marrow biopsy and full skeletal and organ scan because of the connection of MGUS to lesions and disease in the body. So far my bone marrow biopsy and full skeletal CT are normal and I am having the full body CT in 2 weeks. I agreed to these diagnostic procedures because my MGUS markers have not stabilized since 2021 and are gradually moving out of range although my hematologist stated that my markers are better than most of his other MGUS patients. So it makes sense to me that MGUS (constant inflammation) can contribute to increased risks of other disease.

Makes sense to me. Thank you for posting this.🤠

Thank you for posting this.

I live in Boise, Idaho, where I was diagnosed by a local hematologist who said I had MGUS. I went to Mayo Rochester where I was retested and told I did not have MGUS. I have had autoinflammatory illnesses since at least the age of 9. Since the incorrect diagnosis here, I have spoken to others about my diagnosis issue in what I often refer to as a "medical desert" (no thanks to our anti-science, anti-vax, anti everything legislators who keep supporting a coroner who had his medical license removed in another state). I have heard from many in town who also claim to have MGUS--seems like Boise is having an epidemic of a rare disease. My warning to all is that you get your diagnosis from a reputable doctor at a reputable institution like many of our top teaching-research hospitals.

Thanks for this. I was dx w/ MGUS after having Prostatectomy - gland was 2/3 cancer cells & bigger than a golf ball. Never had symptoms & did not recoup very well after surgery. Good Pelvic Floor PT specialist told me to get to an Onc/Hematologist immediately. Blew me out of the water at the time. Found a wonderful Onc/Hematologist that I was lucky to get w/. It took him 2.25 yrs to get the MGUS dx. My blood counts were weird but he did not go the MGUS route until close to the end of the time. Then full bore - blood draws sent to a special lab, PET scan (full body), BMB. Yep, MGUS!! My RBC & WBC are weird. Plus my M spike is now increasing and has been gradually, but to boot my PSA is now fluctuating. Onc/Hematologist I now have worked at Cleveland Clinic and watches me like a hawk. Was on 6 mos review but if M spike is still climbing, I am guessing it will be every 3, same as when she picked me up from the previous guy. Have also had some skin cancers which raises some eyebrows. So it is what it is. I am still working at 70 and try to stay healthy. Am full diabetic w/ CGM and watch closely what I am eating. Constantly changing diet as I find even the “healthy” stuff does things on my glucose level. I have 3 out of 7 symptoms listed by Mayo. Plus now I am dealing w/ my wife starting to have cognitive issues which increases my stress quite a bit. I don’t feel so bad after reading some of the issues people have, just plodding along and trying to enjoy life.

Good day everyone,
I posted this info to make people aware of the new research that is being done on MGUS and Non-Hematologic Malignancy. What was nice about this study compared to others throughout the Science Journal (Pubmed etc.) space, was the size of the study being over 33K observed. I also want people to be aware that AGE matters with MGUS, I was DX at 36, while most will be DX 65+, and with a 1% chance each year of progression to MM, most people will be fine. Also, multiple studies going back 10-15 years have shown many people will get diagnosed or pass from other forms of cancer and/or other health related diseases/conditions. I am going through a breast situation right now and telling your doctors and specialists about your bloodwork and BMB results is important. Your BMB will show things like the deletion of a particular chromosome that has shown a relation to tumor growth. So, eat clean, eat healthy, put down the fake sugars, genetically modified food and chemically created food dyes etc. Eat like they do in Italy, fresh, fresh, fresh.