Methotrexate & Nexium - drug interaction?

You might check Drugs.com or ask your pharmacist.

@nettsie I was on Lansoprazole (which is a proton pump inhibitor too); at the time I started taking Methotrexate and I didn’t experience drug interaction, but as @tillymack suggests, check drugs.com or ask your pharmacy. Both have been my go to sources for information. I was taken off Methotrexate (which I was prescribed for psoriasis) after about four years because of concern that long term use might affect my fatty liver disease.

Thank you very much for the information. I greatly appreciate it.

@nettsie I have read many comments on PPIs (proton pump inhibitors) not being advisable for long term use, but I have been on Lansoprazole for over twenty years now because of GERD due to a small hiatal hernia. So far it has neither affected me adversely nor interfered with any prescription medications I have taken since I started on Lansoprazole.

Drugs.com still is my go to site to check up on interactions with any new prescription medications I take - it even informs you of interactions with food, and I think supplements, too. I have opened an account on that site and have all my prescription meds listed on the site so I can know at a glance if there might be contraindications.

Become friendly with your pharmacist. I developed a great respect for pharmacists and nurses during the few years I worked part time as a unit clerk in the Surgical Intensive Care Unit (SICU) at a hospital in Toronto. Now I trust their advice more than I do my doctors! 😀

I'm not sure about the drug interaction question.

But do be sure to keep an eye on your calcium levels and get a baseline bone density scan.

Nexium is a great medicine. GERD can lead to cancers, so keeping it in check is important. But PPIs have side effects.