@nettsie I was on Lansoprazole (which is a proton pump inhibitor too); at the time I started taking Methotrexate and I didn’t experience drug interaction, but as @tillymack suggests, check drugs.com or ask your pharmacy. Both have been my go to sources for information. I was taken off Methotrexate (which I was prescribed for psoriasis) after about four years because of concern that long term use might affect my fatty liver disease.