Metformin and ADT

Yes, in my previous post I mentioned that I wonder if semaglutides have similar effect and yesterday I did some reading - and yes - there are promising studies done. You can Google yourself. If you have any trouble finding info. please feel free to PM me and I will send you links. The effect of all of those drugs is not through lowering glucose per se. I try to repeat it over and over again, Metformin and semaglutides do not lower glucose directly but with different metabolic pathways that effect tissue and cells regardless of if somebody has diabetes or not. It is NOT through glucose lowering that those drugs effect prostate cancer.
So yes- it could be positive thing that you are on Ozempic now :).

Phill - I am repeating over and over , it is NOT glucose lowering effect of Metformin and samaglutides that effects cancer cells.

Please when you find time read about pathways in which drugs like that help.

No singular thing will work for everybody. But those are very promising findings. Goodle "samaglutides and prostate cancer," for example.

I am trying to concentrate on what might help and what is possibly promising - I have no idea why that tragic story was part of this discussion. I repeat - M. and S. effect has NOTHING to do with sugar levels or sugar in diet in regard of how they effect cancer cells and body in general *sigh.

Deebee, being a chemist makes you uniquely qualified in this arena. Thanks for your input!
Phil

OK, my turn to “sigh”… I KNOW that both of these drugs improve metabolic pathways and their benefit is NOT simply in lowering glucose; more importantly, they prevent hyperinsulinemia, which is a direct reaction to elevated glucose levels. That’s a whole metabolic cascade way above my pay grade.
If you look back on the very first post in this thread, @jeffmarc cited the STAMPEDE trial which showed improved metabolism for a variety of levels, including lipids. So it was never just about lowering glucose.
But you cannot imagine the many, many debates about glucose that have appeared on this forum in the past year or so - way before you joined. This recurrent excess glucose/sugar causing cancer topic has been championed/debunked by just about everyone on here…it’s almost scary how much false information is still being dispatched online.
So I include the tragic passing of my friend’s son to illustrate that no amount of glucose deprivation, no metformin, no Ozempic are gonna do diddly squat if you have an aggressively deadly cancer.
All these little tidbits may be “promising” or “exciting” but when you have the “really bad cancer” as my grandmother used to say, your chances of survival are less than 10%.

The ever-evolving glucose wars—half endocrinology, half street fight, all conducted from the comfort of a keyboard. It’s like watching gladiators in lab coats arguing about carb ratios while Rome burns quietly in the background. We so wanna believe in “magic potions”. Alas…

You're right, of course. If Ozempic and metformin were the magic bullets some folks think they are, oncologists would’ve packed up and joined dermatology years ago. But alas, cancer doesn't read forum posts or randomized trials. It just mutates and marauds like a drunk pirate with a grudge.

As for the STAMPEDE trial—it's the Rorschach test of metabolic interventions. Everyone sees what they want in it. Improved lipids? Sure. Extended survival? Maybe. Vindication for their smoothie-based lifestyle? You bet.

And yeah, once you’ve seen someone you care about mowed down by the genetic freight train of aggressive cancer, you realize that no amount of artisanal kale or molecular-level insulin whispering is going to change the outcome.

There’s a point where the machinery just breaks, and all the metabolic tinkering in the world amounts to moving deck chairs on the Titanic—with a Fitbit on.

So sigh away. You’ve earned it. Just don’t forget to exhale.