Metformin and ADT

This is July 2024 metformin and prostate cancer From nature
https://www.nature.com/articles/s41391-024-00871-7

Yeah, Jeff, that’s the one! With your computer background you must be scratching your head at my digital ineptitude!

Well, THAT is my main point. How do you get an RX if you are not diabetic? Right now, you can’t so until it becomes like aspirin for cardiovascular disease, it’s a real issue.
There’s a lot they need to study here; metformin is NOT a cure all for cancer. In fact, actual controlled breast cancer studies showed that it did not have any benefit at all for EITHER type of cancer - estrogen positive or negative.

I started Metformin a while before prostate cancer diagnosis.I had 45 radiation sessions and 2.5 years of 3 month Lupron. PSDA stayed low for about 8 years then stared to rise slowly. Still take Metformin daily. PSA doubling time is about 17 months. Having new PSA and bloodwork test done next week.

If you have a good and flexible doctor he/she will prescribe it "off label" . Once I was prescribed medication "off label" by a doctor because I brought with me research papers that showed those meds. help in my particular case (in study done in Canada) . I had to change 5 doctors and dentists until I found fantastic oral pathologist who was open to suggestions since she really wanted to help and medication DID help 100 %. Also, Metformin can be ordered online 😉 via "telemedicine" *wink wink, since it is such benign and extremely cheep medication. Two or 3 of us here tried to tell you couple of times that it is not strictly diabetes medication and does not effect glucose levels directly. On the other hand it is completely understandable if you do not feel comfortable trying it without doctor's approval. I for a fact know that there are doctors who like to think out of the box and prescribe medications that are promising in some papers or show better results. My friend who has thyroid problems was prescribed synthetic hormone and it was not helping very much. She read that natural hormone got from pigs helps better in such cases. Actually, initial discovery of hypothyroidism treatment was conducted with natural hormones from pigs but guess what - soon pharma took over with synthetic hormone production since that way they charge more. Anyhow - she finally found a doctor who prescribed her pig hormone granules which are made in compounding pharmacy and she is now like new person !

Metformin absolutely is not cure all, nothing is ;), not even chemo nor radiation or any other treatment.

So the take-away is that it is not the wonder drug we all think it is?
What is your feeling about your results - positive? Neutral?

This is very interesting; as I am on Ozempic trying to reduce sugar/glucose... and I wonder whether it has a similar effect as Metformin .. to wit: it's the reduced presence of glucose that presumably matters (it is known as fuel for PC) .. rather than which medication causes the glucose reduction. That's what I'm postulating and hope someone has thoughts on.. cheers!

I have long known about metformin’s “supposed” use as an anti/cancer agent. One of my own patients - a physician - treated his Gleason 6 with metformin, doxycycline and aspirin and it was downgraded to PIN on his next biopsy; this was over 7 yrs ago and he moved out of the area so I don’t know what ultimately happened.
I am certainly not against the use of orphan drugs because hey, you just never know…
But as one cancer researcher once told me, “cancer always finds a way”. If the genetic makeup of your cancer is very aggressive as in glioblastoma or neurendocrine (pancreatic) cancer you have a MUCH greater chance of dying, rather than surviving.
She told me that she had seen many aggressive cancers respond initially to immunotherapy, only to quickly overwhelm the drug and actually use it as food.
My best friend’s son had this exact experience - multiple metastases AFTER a course of immunotherapy.
BTW, his wife was a nutritionist and cut ALL sugar from his diet just days after his diagnosis. He was dead in 18 months.

Being a chemist and knowing a bit about how Metformin works on cell I give it a neutral. Maybe just my body though.

I’m so sorry that’s awful