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Lymphovascular invasion

Posted by johndavis60 @johndavis60, Jun 4, 2025

Anybody have “Lymphovascular invasion” on their biopsy or prostate pathology after surgery? If so, what did doctors say/do about it?

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Jeff Marchi | @jeffmarc | Jun 4, 2025

Lymphovascular invasion (LVI), found in a prostate cancer biopsy, suggests that cancer cells are present within lymph or blood vessels, which indicates a higher risk of the cancer spreading. This finding is often associated with more aggressive prostate cancer, higher PSA levels, higher Gleason scores, and advanced tumor stages. LVI can also be linked to a higher likelihood of lymph node involvement and a greater chance of recurrence after Treatment.

Did they remove lymph nodes during surgery?

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johndavis60 | @johndavis60 | Jun 4, 2025
In reply to @jeffmarc "Lymphovascular invasion (LVI), found in a prostate cancer biopsy, suggests that cancer cells are present within..." + (show)
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Lymphovascular invasion (LVI), found in a prostate cancer biopsy, suggests that cancer cells are present within lymph or blood vessels, which indicates a higher risk of the cancer spreading. This finding is often associated with more aggressive prostate cancer, higher PSA levels, higher Gleason scores, and advanced tumor stages. LVI can also be linked to a higher likelihood of lymph node involvement and a greater chance of recurrence after Treatment.

Did they remove lymph nodes during surgery?

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Yes, 19 and they were all clear. I believe my urologist is going to refer me to oncology where they will probably give me radiation, ADT and / or chemo. Who knows. I had positive margins so they told me I would be getting more treatment when I came out of surgery.

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anosmic1 | @anosmic1 | 1 day ago

John: I occasionally search for factors I found in my post-op report from RP surgery in 11/2024. This discussion popped up in today's search because LVI was one of my adverse factors. I also had Perineural invasion (PNI), bladder neck invasion (BNI), cribriform, positive margins and intraductal. We sound similar. I was diagnosed at 66 and will be 69 in November.

My PSA only rose as high as 0.04 at 11 months, but because of those factors and Gleason 4+5 we moved ahead with Lupron (6-month injection last October) and 39 radiation treatments ending in early February. I've been undetectable but my next PSA check is in 3 weeks, which is about the time I obsess again.

I'm curious whether you've had further treatments or developments. The nightmare in my mind has an eventual recurrence and chemo. I've heard too many stories about chemo and don't want to go there. I'm curious whether your treatment led down a similar path / Tom

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johndavis60 | @johndavis60 | 23 hours ago
In reply to @anosmic1 "John: I occasionally search for factors I found in my post-op report from RP surgery in..." + (show)
Profile picture for anosmic1 @anosmic1

John: I occasionally search for factors I found in my post-op report from RP surgery in 11/2024. This discussion popped up in today's search because LVI was one of my adverse factors. I also had Perineural invasion (PNI), bladder neck invasion (BNI), cribriform, positive margins and intraductal. We sound similar. I was diagnosed at 66 and will be 69 in November.

My PSA only rose as high as 0.04 at 11 months, but because of those factors and Gleason 4+5 we moved ahead with Lupron (6-month injection last October) and 39 radiation treatments ending in early February. I've been undetectable but my next PSA check is in 3 weeks, which is about the time I obsess again.

I'm curious whether you've had further treatments or developments. The nightmare in my mind has an eventual recurrence and chemo. I've heard too many stories about chemo and don't want to go there. I'm curious whether your treatment led down a similar path / Tom

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@anosmic1
Hey Tom, yes we are alike!
After I did my prostatectomy in May ‘25, I did 38 session of radiation from September to December. They also put me on Firmagon monthly shot and abiraterone. I have been undetectable at <.02 for almost a year. I get my psa checked every month and I know the anxiety well.
I haven’t done chemo but I’m sure it’s just a matter time. Hopefully not for a couple years anyway.

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