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Lupron: Anyone have muscle weakness and severe leg pain?

Posted by kam23 @kam23, Jul 14, 2023

I have PC and have been on Lupron injections every 3 months for 15 months. I am experiencing severe leg pain in hamstrings and glutes. Has anyone else experienced this or tried monthly shots?

This has been getting worse for the last 3-4 weeks. I’m afraid I’ll be in a wheelchair or have to stop this form of testosterone elimination therapy.

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maga | @maga | Jun 26 7:11am
In reply to @bonjas "Oh on the other note Eligard makes your sex drive to zero you are literally chemically..." + (show)
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Oh on the other note Eligard makes your sex drive to zero you are literally chemically castrated during your treatment period.

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@bonjas I was on Lupron for 2 years. I got my last injection last march. I still have no sex drive. Since my testosterone is only 16. I guess I have to wait until it goes higher. I believe normal is between 300-900. I don't want to take testosterone because of possible side effects.

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bonjas | @bonjas | Jun 26 9:04am
In reply to @maga "@bonjas I was on Lupron for 2 years. I got my last injection last march. I..." + (show)
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@bonjas I was on Lupron for 2 years. I got my last injection last march. I still have no sex drive. Since my testosterone is only 16. I guess I have to wait until it goes higher. I believe normal is between 300-900. I don't want to take testosterone because of possible side effects.

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@maga you are definitely right, when you said last March is it last year March or this year, testosterone takes time to build back up after Eligard treatment it is a good idea not to take testosterone meds

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maga | @maga | Jun 26 2:39pm
In reply to @bonjas "@maga you are definitely right, when you said last March is it last year March or..." + (show)
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@maga you are definitely right, when you said last March is it last year March or this year, testosterone takes time to build back up after Eligard treatment it is a good idea not to take testosterone meds

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@bonjas It is this year. I read that lifting weights can increase testosterone. I have been doing that for a long time.

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maga | @maga | Jun 26 2:41pm

I aso have a pain that hurts l

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maga | @maga | Jul 5 6:25am
In reply to @beulah4 "I have been on Lupron since June, 2016. I have injections every six months over a..." + (show)
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I have been on Lupron since June, 2016. I have injections every six months over a two year period. This is followed by what my oncologist calls a “Lupron Vacation” until my PSA begins to rise. My doctor says I have had an A+ response to Lupron.
Over the past six months I have begun to experience muscle pain in my thighs and lower legs. Has anyone experienced this reaction?

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I was on Lupron for 2 years. After the last Lupron injection I started getting leg pain on my left leg. i still have pain after the last injection which was 4 months ago.

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guybe | @guybe | Jul 6 6:57am
In reply to @maga "I was on Lupron for 2 years. After the last Lupron injection I started getting leg..." + (show)
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I was on Lupron for 2 years. After the last Lupron injection I started getting leg pain on my left leg. i still have pain after the last injection which was 4 months ago.

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@maga Have you tried a foam roller or massage gun?

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maga | @maga | Jul 6 9:39am
In reply to @beulah4 "I have been on Lupron since June, 2016. I have injections every six months over a..." + (show)
Profile picture for beulah4 @beulah4

I have been on Lupron since June, 2016. I have injections every six months over a two year period. This is followed by what my oncologist calls a “Lupron Vacation” until my PSA begins to rise. My doctor says I have had an A+ response to Lupron.
Over the past six months I have begun to experience muscle pain in my thighs and lower legs. Has anyone experienced this reaction?

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No I haven't. What does a foam roller do?

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Sicetnon3 | @sicernon3 | Jul 6 10:55am
In reply to @beulah4 "I have been on Lupron since June, 2016. I have injections every six months over a..." + (show)
Profile picture for beulah4 @beulah4

I have been on Lupron since June, 2016. I have injections every six months over a two year period. This is followed by what my oncologist calls a “Lupron Vacation” until my PSA begins to rise. My doctor says I have had an A+ response to Lupron.
Over the past six months I have begun to experience muscle pain in my thighs and lower legs. Has anyone experienced this reaction?

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After I quit Lupon , I developed pain in my right shoulder which prompted me to have an c-ray. It revealed mild osteo-arthritis.

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chippydoo | @chippydoo | Jul 7 9:13am
In reply to @maga "No I haven't. What does a foam roller do?" + (show)
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No I haven't. What does a foam roller do?

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@maga Myofascial release. That is the tissue that surrounds your muscles. It can get sticky where two muscles touch. Massage therapist actually get their fingers into the edges which is comfortable but helps with recovery if over worked. The roller can also "roll out" knots in your muscles. Are you by chance taking a statin? Statins can also cause thigh pain.

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boki01 | @boki01 | Jul 7 12:27pm
In reply to @beulah4 "I have been on Lupron since June, 2016. I have injections every six months over a..." + (show)
Profile picture for beulah4 @beulah4

I have been on Lupron since June, 2016. I have injections every six months over a two year period. This is followed by what my oncologist calls a “Lupron Vacation” until my PSA begins to rise. My doctor says I have had an A+ response to Lupron.
Over the past six months I have begun to experience muscle pain in my thighs and lower legs. Has anyone experienced this reaction?

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Hello,
May I ask what your Gleason score and prostate cancer stage were before you started Lupron treatment?
Wishing you all the best.

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