Lupron

Posted by beulah4 @beulah4, Sep 6, 2025

I have been on Lupron since June, 2016. I have injections every six months over a two year period. This is followed by what my oncologist calls a “Lupron Vacation” until my PSA begins to rise. My doctor says I have had an A+ response to Lupron.
Over the past six months I have begun to experience muscle pain in my thighs and lower legs. Has anyone experienced this reaction?

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Profile picture for maga @maga

I was on Lupron for 2 years. After the last Lupron injection I started getting leg pain on my left leg. i still have pain after the last injection which was 4 months ago.

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@maga Have you tried a foam roller or massage gun?

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No I haven't. What does a foam roller do?

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After I quit Lupon , I developed pain in my right shoulder which prompted me to have an c-ray. It revealed mild osteo-arthritis.

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Profile picture for maga @maga

No I haven't. What does a foam roller do?

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@maga Myofascial release. That is the tissue that surrounds your muscles. It can get sticky where two muscles touch. Massage therapist actually get their fingers into the edges which is comfortable but helps with recovery if over worked. The roller can also "roll out" knots in your muscles. Are you by chance taking a statin? Statins can also cause thigh pain.

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Hello,
May I ask what your Gleason score and prostate cancer stage were before you started Lupron treatment?
Wishing you all the best.

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