Low IgG and low IgA

Hi @tjanet, Not trying to panic you, have you been referred to a Hematologist/Oncolgist or an Oncologist for additional tests? Was your IgM also tested? Was it high, low, or normal?

My IgM was normal. But my IgG and IgA were low.
I saw a Immunologist but I haven't seen a Hematologist.

Hematologist for sure. I am now in monthly IV replacement ( human ). Had alarming low IGg but High A and normal M. After 6 months I am about to break into the low range of IGg. Have less fog head and energy ( I am dealing with lots of other things too tho’ - am on immune suppressant for RA- but works differently - didn’t cause other.
I felt nothing before - but big fatigue. An immunologist found mine too! Thank god! Best of luck with you!

Surprised you haven't been referred to check for Myeloma. Good luck.

Do you have IgG Myeloma? I have Smoldering IgA Lamba, with almost IgM and really low IgG. I take Prednisone daily for PMR. Good luck, I hope you feel better.

No myaloma - yet - as I do have MGus. Is that a possible connection I am not aware of!? I too take Prednisone daily ( 35 years) for Asthma first and then RA for 30 years ( can’t get lower than 5 mg now). Also biologic IV for RA ( and others). Fun isn’t it!?

I get monthly IVIG infusions. Have been getting them for the past year. Leveled out my counts. My damage was a result of treatment for my GPA, not a new disease. Rheumatologist and immunologist both at Mayo. Neither recommended seeing a hematologist. I feel surprisingly better than I have in years.

Oops. That should read 'almost no' IgM, it's really really low as well as really low levels of IgG.

Hi, I'm in the UK and was diagnosed with MGUS in 2012. My bloods are checked for 'everything' every 6 months and back in 2018 whilst trying to find travel insurance for a holiday to Greece and being met with extortionately elevated costs, I contacted my consultant haematologist to enquire what if anything else I could say it was, as MGUS seemed to be conjuring up wild thoughts with insurance companies...he advised that as my levels were low and had been static for 6 years, I could call it 'benign paraproteinaemia'. This made a staggering difference to my insurance from £450 extra on top of my already existing annual cover, to only £20 extra! Now that's not to say that every case of MGUS can be downgraded that way...but it may be worth you keeping that in mind when you've got a few years under your belt with static results. It felt far less of a developing lymphoma threat to me from what I'd read and understood. I was given little or no advice in the early days of my diagnosis and underwent many tests, scans and a bone marrow biopsy too whilst the medics were researching everything about me...weekly bloods were done for 4 months, then once a month, to once every 3 months and then eventually after a few years at 6 monthly, it was changed to 9 monthly and although my levels have remained unchanged, due to me then being in my mid 60's, they reverted to 6 monthly bloods. That was 6 years ago. My risk factors of developing myeloma, leukaemia, lymphoma or bone marrow cancer, are currently relatively low I'm told as its been more than 10 years, but could increase with age apparently...or maybe not. In the beginning I was frightened of my newly acquired diagnosis and it felt like a ticking time bomb inside me...however, I barely think about it now. It's 12 years since my diagnosis. I do though have other auto immune conditions though which I've had pre and post MGUS diagnosis. It is written that there are increased risk factors than can be linked....cardiovascular disease etc...I have developed atrial fibrillation and subsequently had a stroke as my untreated hypertension and AF caused it. Additionally I have lipoedema, did have asthma for 20 years (misdiagnosed I think) rheumatoid and osteo arthritis, tendonopathy, spinal stenosis, Sjögren's Syndrome and Raynaud's. I have 2 hip replacements and am awaiting 2 new knees...bionic! I'm still smiling for the most part albeit sometimes through secret tears. So with all the other stuff I really don't give MGUS/benign paraproteinaemia too much power over my thoughts/emotions. I live by the phrases, 'I'll cross that bridge when I come to it'.along with ..'It is what it is'...and 'on with the fun'! 😊🫂

I have had IgA kappa MGUS for 8 years (I'm 70). Some people have IgG or IgM and/or Lambda MGUS. My IgG and IgM levels are very low but my IgA inflammation is elevated. There is a 1% risk per year of MGUS progressing to smoldering multiple myeloma (SMM) or to MM, so pretty low. MGUS is a waiting game, mostly checking bloodwork a few times a year to see changes in the Kappa, Lambda, and various other markers. It would be good to get more info from your doctor on your MGUS and IgG, IgA.