I don't think that I have ever been tested for CHEK2 mutation. I was tested for BRCA and that was negative and I was tested for Gene TSC2 Tuberous sclerosis complex and the result was called Uncertain Clinical Significance meaning genetic change that may or may not be contributing to cancer risk.
I have a suspicion that I have some kind of a genetic issue. My mom and sister both had lung cancer and my sister had breast cancer and my grandmother had bladder cancer and my uncle had prostate cancer. I have had benign breast, thyroid, uterine, wrist, colon, knee and finger tumors that were removed. Also, I had 2 different kinds of breast cancer and 1 skin cancer surgery. And I have severe osteoarthrits.
I looked it up and the odds of having CHEK2 is 1.6% and the odds of having Low grade adeno squamous carcinoma is less than 1%. Knowing that you both have both genetic factors is interesting to me. I have a follow up appointment with my radiation oncologist and I think I will bring this up to her in a few weeks.
Have either one of you had an issue with benign tumors, cysts or osteoarthritis?
Thanks for the information. I appreciate it.
Katrina123
@katrina123
It is interesting! I didn’t even know that I was tested for the CHEK2 mutation but At my last appointment my oncologist brought it up and explained it to me. Would definitely be worth asking though. You will have to keep us posted!
Yes, recently I have had to get 2 Myxoid cysts removed….from my toes of all places! These cysts are connected to the joint and have joint fluid inside of them. I asked the doc why I’m getting them and he said he’s not sure but usually has to do with arthritis.
I also have Hashimoto’s Thyroiditis which is an autoimmune disease. Anyone else have that?
I have been trying to see what similarities I share with others who have had LGASC since I was diagnosed. Maybe we will get it figure out, Lol!
I don't think that I have ever been tested for CHEK2 mutation. I was tested for BRCA and that was negative and I was tested for Gene TSC2 Tuberous sclerosis complex and the result was called Uncertain Clinical Significance meaning genetic change that may or may not be contributing to cancer risk.
I have a suspicion that I have some kind of a genetic issue. My mom and sister both had lung cancer and my sister had breast cancer and my grandmother had bladder cancer and my uncle had prostate cancer. I have had benign breast, thyroid, uterine, wrist, colon, knee and finger tumors that were removed. Also, I had 2 different kinds of breast cancer and 1 skin cancer surgery. And I have severe osteoarthrits.
I looked it up and the odds of having CHEK2 is 1.6% and the odds of having Low grade adeno squamous carcinoma is less than 1%. Knowing that you both have both genetic factors is interesting to me. I have a follow up appointment with my radiation oncologist and I think I will bring this up to her in a few weeks.
Have either one of you had an issue with benign tumors, cysts or osteoarthritis?
Thanks for the information. I appreciate it.
Katrina123
@mchler73 - I definitely am not qualified to have an informed opinion on this! However, it is interesting that those two data points align for us both. I will definitely let my oncologist know! My bilateral mastectomy/reconstruction is this coming Wednesday.
@susan7656
Do you know if your genetic testing shows a CHEK2 mutation ? I was diagnosed with LGASC in 2023 and at that time, was told my genetic testing came back negative but at my last oncology appointment my doc said that I have the CHEK 2 mutation and it has been linked to breast, prostate and colon cancers.
With LGASC being so rare, I am still trying to find similarities with others who have had it.
Thanks!
I, too, have been diagnosed with this rare breast cancer - stage 1B low grade Adenosquamous carcinoma. I would love to know how @katrina123, @cheeta and @lilybird are doing. My bilateral mastectomy and reconstruction are next week.
@susan7656
Do you know if your genetic testing shows a CHEK2 mutation ? I was diagnosed with LGASC in 2023 and at that time, was told my genetic testing came back negative but at my last oncology appointment my doc said that I have the CHEK 2 mutation and it has been linked to breast, prostate and colon cancers.
With LGASC being so rare, I am still trying to find similarities with others who have had it.
Thanks!
I had a lumpectomy in 2020 for the Low Grade Adenosquamous metaplastic carcinoma followed by 4 weeks of radiation in one breast and so far it hasn't returned. Unfortunately, in January of 2024 I had a breast cancer lumpectomy surgery in the other breast for invasive ductal carcinoma and following surgery I had another 4 weeks of radiation. A few months later I had Moh's surgery on my face for basal cell carcinoma. Hopefully I won't have any more cancer.
Low grade adenosquamous carcinoma is a very serious cancer and I think you are doing the smart thing by having a mastectomy. I have a rare immune disease and I did not feel confident that that would be the best way for me to go.
I will be thinking of you, and I know everything will go O.K. Please keep us informed and let us know how you are doing.
I, too, have been diagnosed with this rare breast cancer - stage 1B low grade Adenosquamous carcinoma. I would love to know how @katrina123, @cheeta and @lilybird are doing. My bilateral mastectomy and reconstruction are next week.
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@katrina123
It is interesting! I didn’t even know that I was tested for the CHEK2 mutation but At my last appointment my oncologist brought it up and explained it to me. Would definitely be worth asking though. You will have to keep us posted!
Yes, recently I have had to get 2 Myxoid cysts removed….from my toes of all places! These cysts are connected to the joint and have joint fluid inside of them. I asked the doc why I’m getting them and he said he’s not sure but usually has to do with arthritis.
I also have Hashimoto’s Thyroiditis which is an autoimmune disease. Anyone else have that?
I have been trying to see what similarities I share with others who have had LGASC since I was diagnosed. Maybe we will get it figure out, Lol!
mchler73 and susan7656
I don't think that I have ever been tested for CHEK2 mutation. I was tested for BRCA and that was negative and I was tested for Gene TSC2 Tuberous sclerosis complex and the result was called Uncertain Clinical Significance meaning genetic change that may or may not be contributing to cancer risk.
I have a suspicion that I have some kind of a genetic issue. My mom and sister both had lung cancer and my sister had breast cancer and my grandmother had bladder cancer and my uncle had prostate cancer. I have had benign breast, thyroid, uterine, wrist, colon, knee and finger tumors that were removed. Also, I had 2 different kinds of breast cancer and 1 skin cancer surgery. And I have severe osteoarthrits.
I looked it up and the odds of having CHEK2 is 1.6% and the odds of having Low grade adeno squamous carcinoma is less than 1%. Knowing that you both have both genetic factors is interesting to me. I have a follow up appointment with my radiation oncologist and I think I will bring this up to her in a few weeks.
Have either one of you had an issue with benign tumors, cysts or osteoarthritis?
Thanks for the information. I appreciate it.
Katrina123
@katrina123
Do you know if you have the CHEK2 mutation?
@mchler73 - I definitely am not qualified to have an informed opinion on this! However, it is interesting that those two data points align for us both. I will definitely let my oncologist know! My bilateral mastectomy/reconstruction is this coming Wednesday.
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2 Reactions@susan7656
Wow that is definitely interesting …I wonder if there is something to that?
Hi @mchler73 - yes, I do have the CHEK2 mutation (heterozygous). That is really amazing that you have it, too.
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1 Reaction@susan7656
Do you know if your genetic testing shows a CHEK2 mutation ? I was diagnosed with LGASC in 2023 and at that time, was told my genetic testing came back negative but at my last oncology appointment my doc said that I have the CHEK 2 mutation and it has been linked to breast, prostate and colon cancers.
With LGASC being so rare, I am still trying to find similarities with others who have had it.
Thanks!
Thank you @katrina123 for the update. I’m really sorry you’ve had multiple cancer challenges. None of it sounds easy.
I’m grateful for your insights.
I will post an update after my surgery.
susan7656
I had a lumpectomy in 2020 for the Low Grade Adenosquamous metaplastic carcinoma followed by 4 weeks of radiation in one breast and so far it hasn't returned. Unfortunately, in January of 2024 I had a breast cancer lumpectomy surgery in the other breast for invasive ductal carcinoma and following surgery I had another 4 weeks of radiation. A few months later I had Moh's surgery on my face for basal cell carcinoma. Hopefully I won't have any more cancer.
Low grade adenosquamous carcinoma is a very serious cancer and I think you are doing the smart thing by having a mastectomy. I have a rare immune disease and I did not feel confident that that would be the best way for me to go.
I will be thinking of you, and I know everything will go O.K. Please keep us informed and let us know how you are doing.
katrina123
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1 ReactionI, too, have been diagnosed with this rare breast cancer - stage 1B low grade Adenosquamous carcinoma. I would love to know how @katrina123, @cheeta and @lilybird are doing. My bilateral mastectomy and reconstruction are next week.