Anyone have Losartan and Folfirinox to shrink PC tumors?

Posted by ch1co2 @ch1co2, Jul 30 1:38pm

Anybody out there have any experience or knowledge regarding the addition of the blood pressure drug Losartin to standard Folfirinox chemotherapy. There is some thinking that the Losartin somehow enables the chemo drugs to better penetrate and kill tumor cells.

Interested in more discussions like this? Go to the Pancreatic Cancer Support Group.

I'm going to mention that to my oncologist


Yes, I am familiar with a patient who was borderline unresectable and had Losartan added to Folfirinox. It shrank the tumor away from the vasculature so that he was able to have the Whipple. It can’t be used on patients with hypotension. Another repurposed hypertensive drug is Bosentan that is effective as well.


Please sign in or register to post a reply.