Anyone have Losartan and Folfirinox to shrink PC tumors?

Posted by ch1co2 @ch1co2, Jul 30, 2023

Anybody out there have any experience or knowledge regarding the addition of the blood pressure drug Losartin to standard Folfirinox chemotherapy. There is some thinking that the Losartin somehow enables the chemo drugs to better penetrate and kill tumor cells.

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jwkelly72 | @jwkelly72 | Jul 30, 2023

I'm going to mention that to my oncologist

stageivsurvivor | @stageivsurvivor | Jul 31, 2023

Yes, I am familiar with a patient who was borderline unresectable and had Losartan added to Folfirinox. It shrank the tumor away from the vasculature so that he was able to have the Whipple. It can’t be used on patients with hypotension. Another repurposed hypertensive drug is Bosentan that is effective as well.

Losartan
https://news.harvard.edu/gazette/story/2019/05/mass-general-trial-shows-novel-protocol-improves-pancreatic-cancer-outcomes/
https://letswinpc.org/my-treatment/2021/08/16/a-clinical-trial-saved-my-life/
https://pubmed.ncbi.nlm.nih.gov/31145418/
Bosentan
https://letswinpc.org/clinical-trials/2022/08/12/hypertension-drug-treatment-for-unresectable-pancreatic-cancer/