Looking for info on GAPPS mutation for Stomach Cancer

Posted by sarahinoz @sarahinoz, Feb 22 1:58pm

I was recently made aware of a family history of a genetic mutation for stomach cancer called GAAPS (APC gene mutation). I'm curious if anyone is this forum has GAAPS or any info on it.

There is a prophylactic recommendation to do a complete gastrectomy - I'd love to get any info I can on what life is like w/o a stomach. I'm in my late 40's and would like to continue will my currently quality of life and unsure if that is still possible - I'd like to remain active (hiking, mtn biking, etc).

Interested in more discussions like this? Go to the Cancer Support Group.

Colleen Young, Connect Director | @colleenyoung | Feb 26 4:31pm

Hi @sarahinoz, I believe you are referring to gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) is a rare variant of familial adenomatous polyposis (FAP). Correct?

While not related to gastric cancer prevention due to FAP, here are two discussions where members are talking about what it is like to have a gastrectomy:
- Anyone familiar with a Gastrectomy (total stomach removal)?
https://connect.mayoclinic.org/discussion/gastrectomy-1/
- Total Gastrectomy for stomach cancer: What can I expect?
https://connect.mayoclinic.org/discussion/total-gastrectomy/

It's not an easy decision to undergo major surgery as a cancer prevention. Are you consulting with a genetic counselor? Are they able to provide information about your relative risk of developing cancer?