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Looking for feedback - Lupron vs Orgovyx

Posted by dwb1 @dwb1, Oct 10, 2024

I discussed changing from Lupron to Orgovyx with my Oncologist today. I am having good results on Lupron with minimal side effects. I would like to here the pros and cons from those of you who have experienced both. Thanks!

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jeff Marchi | @jeffmarc | 13 hours ago
In reply to @harrydalton447 "Hi, my name is Harry. If I may, could I ask you a few questions? Do..." + (show)
Profile picture for harrydalton447 @harrydalton447

Hi, my name is Harry. If I may, could I ask you a few questions?
Do you still have your prostate?
How long have you had your cancer?
Did you do radiation treatment(s)?
Have you tried Orgovyx or Nubeqa?

I had my prostate removed in 2023. 2 Lupron injections. In Jan. 2024, my PSA was .02. Once the 2nd Lupron wore off a few months later, my T went up to 485. I began taking Orgovyx in Sept. 2024 and January , 2025, Dr. added Nubeqa. The side effects are really affecting me. I also found out earlier this year that I have 3 affected Lymph Nodes in my upper abdomen. I stopped taking Nubeqa and now I'm going to stop the Orgovyx and try and talk my doctor in getting me back on Lupron.
Since it's been a year since your post, have you tried Orgovyx or Nubeqa? Have you tried other medication or treatment(s) that you can share? What is your health status now?
I hope to hear from you soon. Take care.

Harry

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@harrydalton447

If you have three lymph nodes with prostate cancer, you need to be very careful about stopping drugs. Nubeqa Has very few side effects and almost everybody says they don’t really feel anything. On the other hand Orgovyx Has a lot of side effects since it reduces your testosterone to under 20. Switching to Lupron will do you no good, It works exactly the same as Orgovyx, Side effects are pretty much the same Because it’s the low Testosterone that’s causing the side effects not the drug itself.

Have you discussed getting those lymph nodes zapped with SBRT Radiation. If they’re accessible to do that, you really want to do it. Removing yourself from the drugs will just make the cancer spread and grow.

I had my prostate removed 15 years ago.
3 1/2 years later, I had salvage radiation because my PSA started rising.
I was on Lupron for six years and switched to Orgovyx. I’m also on Nubeqa. The two together have kept my cancer under control for over two years. The side effects have been identical, whether I’ve been on Lupron or Orgovyx.

When you stop Orgovyx Your testosterone comes back much quicker than if you are on Lupron. That’s a real advantage for most people and since both drugs do the same thing there’s no benefit switching from one to the other. I did it only because it cost me $800 less a year to be on Orgovyx.

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