Looking for causes for elevated liver enzymes

I had my fibroscan done. Only shows mild fatty liver. Still no idea why my liver enzymes went so high. Had more bloodwork done tests done for autoimmune issues. I’m positive antinuclear Ana Crithidia hep 2 Ana and rp11 antibody. No idea if this could be a cause of the liver enzymes. Rheumatologist is no help pcp or gastro have no idea. So I’ve basically decided to just deal with whatever happens.

I have been diagnosed with hemochromatosis I had a gene test and both parents were carriers. I have blood draw once a month to check iron etc, then I have a blood draw ( phlebotomy ) to remove blood to help bring iron and ferritin counts down. Will probably have this procedure the remainder of my life.

I have exactly same issues as yours and my doctor has no answer for me. I have been dealing with this issue at least 5 years.

Try to go to a specialist and do a liver biopsy. I have autoimmune hepatitis stage two. I’m on two medicines and my numbers have drastically been reduced. Also, check your electrolytes as mine were way wacky, and I am now supplementing every day.
Good luck and reach out anytime

I’m still in process of trying to figure out my issue. I had a fibroscan done. Only showed mild fatty liver F1. My numbers have so far stayed normal since the episode in May. I do have an appt with my rheumatologist next week to go over new autoimmune antibody positives. Still waiting for an appt with gastro to see about liver biopsy it’s just so frustrating it’s taking this long

Elevated liver enzymes levels can be a sign of PSC. That is what I have. Confirmed with a biopsy. A GI doctor should be able to determine the cause of your elevated liver enzymes. If he can't then I would find another doctor.

When my primary care doctor (PCP) observed that my liver enzymes were elevated during an annual routine labs, he called me to inquire about any over-the-counter medications/vitamins/supplements or increased alcohol consumption that might be a contributing factor. Since my answer was "No", he told me to stop taking my cholesterol prescription medication and to have my labs repeated. Unfortunately, the enzymes remained elevated. He then referred me to a gastroenterologist (GI) who began a series of labs and tests to arrive at a cause/reason for the elevated labs. It seemed to take forever! By eliminating potential liver diseses, and with the coordination of a liver specialist, I was eventually diagnosed with PSC as @suerte has mention having. I felt relieved when we had a name for my condition, and for the following 6-7 years, I had labs drawn every 3 months along with a doctor visit to keep tabs on my liver. I eventually progressed to a liver transplant in 2009.
Elevated liver enzymes are common to all liver diseases/conditions from something simple as over-the-counter meds, or alcohol consumption, or an inflamation or infection in the liver. Here is information from Mayo Clinic about elevated liver enzymes:
-Elevated liver enzymes
https://www.mayoclinic.org/symptoms/elevated-liver-enzymes/basics/definition/sym-20050830
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@reppil63 - Good luck next week❤️
@suerte, How are you getting along with your PSC?
@joewu, Are you seeing a specialist like a GI or liver specialist?

For whatever reason, my liver enzymes levels are back in the normal range. Have been for the last 6 or 7 years. Doesn't mean that PSC is gone, just that the liver enzymes are normal. The enzyme levels never fluctuated when I stopped alcohol. The first time the enzymes were found to be high I was 45 years old. A full diagnosis wasn't done until I was about 65. Diagnosis is small duct PSC done with a liver biopsy. Now I am 85 and still going strong. I always figured that I would die with PSC and not from PSC.

@suerte, I'm extremely happy for you! I don't meet many patients with PSC, so it is good to hear from you.
I always knew that my PSC could lead to a liver transplant, and in my case, it did. I was 60 when I received my transplant, and am doing well. I have annual check-ups with my transplant team while continuing routine blood labs every 3 months, and maintaining my antirejection medication schedule.
Are you still being monitored with labs? Do you take any medications for the PSC?

I suffered from chronic IBD for many years. My GI doctor tried a lot of different medications without success. I went to the Mayo Clinic in Scottdale and at that time I was given 2 choices. Go on Remicade or have colorectal surgery. This was about 20 years ago and Remicade was the only Immunol suppressant drug that was available. I went on Remicade for 5 years once a month until my GI doctor told me that it wasn't really working and that the colorectal surgery was the only choice. I had the J-Pouch surgery done 12 years ago in Phoenix so no more Remicade and haven't been seeing a GI doctor on a regular basis. Since IBD and PSC are both associated with an overactive auto immune system my only thought is that maybe the Remicade and then the removal of my colon which was doing more harm than good, may have done something to put my enzymes back in the normal range.