Link between Seroquel and Heart Problems?

Posted by Majic @majic, Nov 5, 2017

My psychiatrist put me on Seroquel approximately 4-5 years ago, on a low dose of 100mg, as a sleep aid.
Apparently it is used as an anti-psychotic in high doses, however in low doses it can be used as a sleep aid because of its anti-histamine properties (that are found in allergy pills for example that make you sleepy).

Fast forward to this past June, and I was diagnosed with Stage 4 Congestive Heart Failure, the “idiopathic cardiomyopathy” kind, idiopathic meaning the doctors don’t know how or why I now have this. It came on VERY suddenly.

I was hospitalized for a week, all of the ‘usual’ tests, and I was free of any clots or blockages. My ejection fraction was 20-25%.
Trying to find a cause:
A virus? I haven’t been sick in a long time, not even a cold.
I have never smoked or used illicit drugs; I have maybe a dozen alcoholic drinks per year, and there is no history of heart failure in my family. So they went through all of my current meds to see if there was a cause.
I have been on Seroquel (100mg), Clonazepam as needed, Wellbutrin, and Citalopram (20mg) for years.
After the doctors did some quick research, the Cardiologist took me off the Seroquel immediately, saying heart failure was a possible side effect, however extremely small the chance might be.

My psychiatrist has since told me “it’s not the Seroquel”.

It’s a long shot, but has anyone been told their Seroquel use led to heart failure?

Thank you for any help.

@stout79 Welcome to Mayo Clinic Connect. You lead a healthy lifestyle but recently you have had bouts of an increased heartrate for no apparent reason. You are wondering if it could be your use of Seroquel. May I ask what your providers advise about your use of Seroquel and your recent heartrate issues and if they have mentioned switching your medications?

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My Cardiologist suggest that I ask my psychiatrist to find a replacement for this medication, but she's tried pretty much everything, SSRI's etc to help with my anxiety and depression and sleep, and the Quetiapine(Seroquel) has been the only thing I could tolerate the side effects of. My psychiatrist doesnt think the heart issues are from the Seroquel. I quit taking the Seroquel cold turkey one day, and after that 24 hour period of not taking the 200mg daily like I have been taking, is when the heart issues started. Even though Im back to taking 200 mg a day, Im having random high heart rate events. A lot at night when Im sleeping.

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@stout79

My Cardiologist suggest that I ask my psychiatrist to find a replacement for this medication, but she's tried pretty much everything, SSRI's etc to help with my anxiety and depression and sleep, and the Quetiapine(Seroquel) has been the only thing I could tolerate the side effects of. My psychiatrist doesnt think the heart issues are from the Seroquel. I quit taking the Seroquel cold turkey one day, and after that 24 hour period of not taking the 200mg daily like I have been taking, is when the heart issues started. Even though Im back to taking 200 mg a day, Im having random high heart rate events. A lot at night when Im sleeping.

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Hi @stout79 . I am 43 year old woman with bipolar. I have been on Seroquel for about 10 years now. My current dose is 200mg at bedtime. I would love to get off it but as soon as I get my taper down to 50mg I end up back at 200mg. I have noticed at random times I get heart palpitations, particularly at night. I have had ECG's aswell but all have a good result. Sometimes I think it is too much coffee but the timing doesn't fit. However, I was also experiencing dizziness and vertigo during the day. My GP tested my thyroid and found I developed hypothyroidism. If your GP hasn't tested for that, it might be worth an ask, maybe.

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Thank you for the response. They did actually just test for that and my bloodwork was good. Just spoke to the cardiologist today and they want to try Corlanor. A medication that helps with those episodes of random high heart rate for long periods.

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@stout79

Thank you for the response. They did actually just test for that and my bloodwork was good. Just spoke to the cardiologist today and they want to try Corlanor. A medication that helps with those episodes of random high heart rate for long periods.

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Well that's something. Good luck!

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@pianista

Yes, I have AFiB and a history of heart issues. They
are tapering me off of it and changing to Latuda.
Still have withdrawals after taking for 6 years. I wish I would have done my homework earlier.

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Hello, I was just reading your guy’s stories. I am 26 and was in rehab when I was 22 and was put on Quetiapine and I’ve been on it ever since just for insomnia. I’ve tried to get off but the withdrawals are just so bad.. I’m on 600MG at night and never really noticed any huge changes until last night it seems. I was trying to fall asleep and my heart all of the sudden rapidly beating… i felt as if I was going to die.. I called 911 and it just started slowing down. So instead I drove myself to the ER and they did an ECG test, chest X-ray and blood tests. They said they all looked good and sent me home. So I started doing my own research because I frankly thought they rushed me out of there and I found this post… I am terrified. I don’t want to take it again but I know that is not an option.. will cutting the dose in half help? If I can get any info from anyone that knows what is going on & if I should worry. I can’t seem to find a medical professional that will take me serious.. it’s Sunday night I have no option but to wait until tomorrow and call my pcp.. Wish I would’ve done my homework… I hope I’m not too late…. thanks. – Andrew

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@andrewj1083

Hello, I was just reading your guy’s stories. I am 26 and was in rehab when I was 22 and was put on Quetiapine and I’ve been on it ever since just for insomnia. I’ve tried to get off but the withdrawals are just so bad.. I’m on 600MG at night and never really noticed any huge changes until last night it seems. I was trying to fall asleep and my heart all of the sudden rapidly beating… i felt as if I was going to die.. I called 911 and it just started slowing down. So instead I drove myself to the ER and they did an ECG test, chest X-ray and blood tests. They said they all looked good and sent me home. So I started doing my own research because I frankly thought they rushed me out of there and I found this post… I am terrified. I don’t want to take it again but I know that is not an option.. will cutting the dose in half help? If I can get any info from anyone that knows what is going on & if I should worry. I can’t seem to find a medical professional that will take me serious.. it’s Sunday night I have no option but to wait until tomorrow and call my pcp.. Wish I would’ve done my homework… I hope I’m not too late…. thanks. – Andrew

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Sent you a private message. Check it

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Last night I felt as if I was going to die, my heart started beating so fast & I felt as if I was going to faint.. It lasted only about a minute.. I went to the ER and they did the ECG & some blood tests and a chest X-ray and everything looked fine is
What they said and blamed it on anxiety and sent me on my way. I feel like they weren’t trying to help me at all. Anyways I did some research linking Quetiapine to multiple cases of heart failure & just cardiovascular problems. People in their 30’s… I am 26 and have never experienced anything like this. I really am scared to take the med now but I really have no choice.. unless I want to go through severe withdrawals.. I feel like I cheated death last night… but maybe I just prolonged it… it’s Sunday night I’ve tried to talk to multiple medical professionals. I plan to call my PCP tomorrow.. if anyone has been through anything similar or has some knowledge about this kind of stuff that would be awesome.. I could really use some good advice.. Thank you

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@andrewj1083

Last night I felt as if I was going to die, my heart started beating so fast & I felt as if I was going to faint.. It lasted only about a minute.. I went to the ER and they did the ECG & some blood tests and a chest X-ray and everything looked fine is
What they said and blamed it on anxiety and sent me on my way. I feel like they weren’t trying to help me at all. Anyways I did some research linking Quetiapine to multiple cases of heart failure & just cardiovascular problems. People in their 30’s… I am 26 and have never experienced anything like this. I really am scared to take the med now but I really have no choice.. unless I want to go through severe withdrawals.. I feel like I cheated death last night… but maybe I just prolonged it… it’s Sunday night I’ve tried to talk to multiple medical professionals. I plan to call my PCP tomorrow.. if anyone has been through anything similar or has some knowledge about this kind of stuff that would be awesome.. I could really use some good advice.. Thank you

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Hi @andrewj1083 and welcome to Mayo Clinic Connect. I am so sorry to hear about your scare last night and that you felt as if the doctors weren't trying to help you. You will notice that I moved your inquiry to the discussion that you were involved with before that is discussing the same thing. Rather than starting a new conversation each time, it's good to post your updates in the same discussion so the people following your experience can share with you in the same place.

This link gives some very good information about the medication that you are taking.
Seroquel: Drug Uses, Dosage & Side Effects: https://www.drugs.com/seroquel.html

Besides a rapid heartbeat, are you having any other symptoms? How long have you been off the medication?

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I didn't have any heart failure problems but when I was on it, I had a heart rate between 100-120 beats a minute consistently. I don't know how many years that took off my life, but I am so glad to be off it for that reason. Furthermore, I am so sorry if it was the Seroquel, I think there could be a possibility. I found it very hard to sleep after they took me off it and then about 2 years after they took me off of it I changed providers, and she put me back on trazodone which seems to do a fine job.

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@andrewj1083

Last night I felt as if I was going to die, my heart started beating so fast & I felt as if I was going to faint.. It lasted only about a minute.. I went to the ER and they did the ECG & some blood tests and a chest X-ray and everything looked fine is
What they said and blamed it on anxiety and sent me on my way. I feel like they weren’t trying to help me at all. Anyways I did some research linking Quetiapine to multiple cases of heart failure & just cardiovascular problems. People in their 30’s… I am 26 and have never experienced anything like this. I really am scared to take the med now but I really have no choice.. unless I want to go through severe withdrawals.. I feel like I cheated death last night… but maybe I just prolonged it… it’s Sunday night I’ve tried to talk to multiple medical professionals. I plan to call my PCP tomorrow.. if anyone has been through anything similar or has some knowledge about this kind of stuff that would be awesome.. I could really use some good advice.. Thank you

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I truly believe the Seroquel could be behind the racing heart. When I was on it, I always had a heart rate over 100 beats/minute. I never had it get to the point yours did, but I believe if you have any anxiety and if you typically have a high resting heart beat it could easily push you up to that high heart rate. Why do you say you have no other choice, I would think a doctor could wean you off of the Seroquel and put you on something that would tax your system less. I advise you to keep looking for a psychiatrist or psychiatric nurse practitioner who will help you with this. I got weaned off of it and although the sleep was a nightmare for 2 years, I found someone who got me on trazodone for sleep.

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Hi,
I ran across this thread while posting in another and it caught my attention. I’ve been on 50 mg of seroquel for insomnia for several years (a horrible med for insomnia alone!). I’ve also been struggling with bouts of a racing heart. I thought it was due to anxiety (though my thoughts aren’t anxious at the time) or too much caffeine or nicotine. I am prescribed propanalol as well for anxiety, and have been taking it when my symptoms start, but now I am noticing I need the propanalol twice daily. I saw my provider today, and switched to trazodone for sleep. I’ll let you know if this helps my symptoms.

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