1. < Autoimmune Diseases
Profile picture for gaggy

Anyone using Methotrexate for treating Lichen Sclerosis?

Posted by gaggy @gaggy, Nov 17, 2025

Can anyone share their experience and outcome of Methotrexate treatment for Lichen Sclerosis? I’m in second week. Thank you.

Interested in more discussions like this? Go to the Autoimmune Diseases Support Group.

Profile picture for cher51
cher51 | @cher51 | Nov 21, 2025
In reply to @ddn "I use Clobetasol Propionate ointment and it has controlled my symptoms. What is Methotrexate?" + (show)
Profile picture for ddn @ddn

I use Clobetasol Propionate ointment and it has controlled my symptoms. What is Methotrexate?

Jump to this post

@ddn I do as well. I use to use Methotrexate for my inflammatory arthritis. It raised my liver levels.

REPLY
Profile picture for chasity50
chasity50 | @chasity50 | Nov 22, 2025
In reply to @lww "@chasity50 I really feel your pain. For the oral I use rinse called chlorhexidine gluconate and..." + (show)
Profile picture for lww @lww

@chasity50 I really feel your pain. For the oral I use rinse called chlorhexidine gluconate and dexamethasone. About 8 years ago my periodontist suggested I stop using toothpaste and only brush with oral b electric toothbrush. Which I did. I added the use of arm and hammer baking soda as my toothpaste. This combination helped so much that I could manage with the chlorhexidine and dexamethasome. My gums and roof of my mouth are the worse area. Oral has been under control for 5 years. Bout 1mo ago I had a flare up that was really bad but I've been diligent about care and it is getting better. Never cured just bearable. The vaginal has been unbearable for so long I'd forgotten how it felt for it to feel better. Not cured but bearable. I could not use clobetesol at all it just seem to get worse. The desoximetasone ointment that I'm using when I get up in morning and before going to bed at night. I use nothing but water to clean with my fingers. I've tried so many things. Every cream. Creams seem to make it worse. Something I discovered by trial and error trying to get some relief. I have a very soft washrag. I would get it very very warm and insert it around the vulva and hold it for 2 minutes, I would really eased the pain and swelling. I don't know if you have pain and swelling and itching but I really do when it is unbearable. The desoximetasone is the best thing I have used yet. It takes such a small amount. I put it on one side and then the other. I mean a really small amount on each side of vulva.
Hope this helps a little. I've been trying to find it this is hereditary. My mother had it, My sister has it and I have it. Some say yes some say no.

Jump to this post

@lww thank you so much for sharing - this is very helpful! My maternal grandfather had LP on his legs only. Like you, I’ve also heard that yes & no about heredity. My initial oral onset was sparked after 2 root canals & a long period of high stress. I chased a diagnosis thinking it was a food allergy for nearly a year before I started having issues in my throat & was diagnosed w/ esophageal LP in July of this year. Have you experienced any issues w/ lesions in your hands or eyes tearing?

REPLY
Profile picture for lww
lww | @lww | Nov 22, 2025

Yes to throat and ears. In last 2 years I've had two endoscopies and been treated for right ear. I have bouts of not being able to swallow and my right ear swelling and itching. The ear started when I started wearing hearing aids. It goes and comes. Usually by time I get to see doctor it is better. I've been to gastro doctor about swallowing. This last time he did biopsy and it came back with autoimmune gastritis. I personally think it is all related. My first onset of lichen planus was oral. Since you mentioned it. It was about the time I had a root canal. At that time I became allergic to lidocaine in shot form. They biopsied my vaginal and it showed lichen planus. Don't remember biopsy of oral but even I can see it.

REPLY
Profile picture for chasity50
chasity50 | @chasity50 | Nov 22, 2025

I’m not sure what you are using for your ear, but I found Fluocinolone Acetonide Oil - ear drops to be helpful. As for the esophagus, I’ve been taking a compound budesonide suspension & it has helped marginally. I still feel like I have something stuck in my throat.

REPLY
View MoreView Less
Please sign in or register to post a reply.