Lexapro and Mirtazapine - Awful Side-Effects

Posted by odi @odi, May 24 2:51am

Been taking 10mg Lexapro (Escitalopram) in the morning for 1 month for anxiety and depression, but I was not feeling like it making any better. I was feeling nervous and restless whole day with no motivation to do anything.
Doctor said to bump Lexapro to 15mg and added 15mg Mirtazapine at night. Did it for 10 days and I felt more anxious and restless.
Went down to 10mg again. It's been 5 days and I feel like I'm losing my mind. I'm having anxiety crisis, feeling hopeless, feeling like I'm losing control, I can't stop having negative thoughts in my head. I am also feeling tired and sleepy all day, but no matter what I do I can't calm myself down to sleep. I am also taking Xanax 0.25/0.5mg when needed, but even that is not working sometimes.
I could not find any info regarding Mirtazapine being able to cause this type of side-effects. Doctor is not really helpful to determine the problem. Could the restlessness be caused by Lexapro? Should I try a lower dose? I am also scared of lowering the dose having even worse side-effects.
Please, any guidance is welcomed.

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My doc did a swab gene study to see which antidepressant would work best for me. I found the Prozac I was taking for a long time was not the best.
I'm on Lexapro 20 mg which is working, but took 5-6 weeks to really see the difference
This gene study was approved through Medicare, no cost to me.
It's merely a guideline for prescribing the right antidepressant.
My therapist doesn't think it's valid.
Oh well!!!

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@odi
I really thought I had posted a reply to your post but couldn't find it.

I take escitalopram and has worked for. Having said that we are all different and what works for one will not work for another.

You posted about seeing a doctor. Is this a PCP? Have you considered going to a psychiatrist? I was referred to Mayo psychiatric department by my PCP. I devloped PTSD which evoloved into a anxiety/panic disorder. A psychiatric medication specialist can work with you on medication to help you. She/He might want to combine it with counseling.

You mentioned sleeping. A big part of mental and physical health is the ability to sleep. Without it you are really taxing your mental and physical health. There are many sleep aids out there. I could not sleep also and felt terrible like you. My psychiatric medication specialist prescribed Ambien but it did not work for me. She then put me on trazadone which did work. For me it stopped my mind from racing and was then able to get a good night's sleep. Being able to sleep really changed my mental and physical health.

The only con for trazadone for me was feeling groggy in mornings but have read on MCC this is a common side affect and not something specific to me. The ability to sleep far outweighed the con of feeling groggy in morning.

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@gingerbear22

My experience with Mirtazapine was bizarre and life-threatening. I had the most intense, ugly, violent, bizarre dreams by night and by day was the most suicidal I had felt in years. It had been prescribed by my GP.
To exacerbate the problem they were not available when I needed them most.

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You sound exactly like me when taking Mirtazapine, I not only had everything from anxiety, restlessness in my legs and it didn’t help me sleep but when I did my dreams turned into nightmares like something out of a horror movie…to top it off my doctor who prescribed it for me was unavailable to the reach, eventually I just started tapering myself off weekly until I was done. I don’t want to put down a medication because even if I didn’t feel well from it I realize that for others it works well, the only good thing I got from the med was a well needed appetite.

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I have been using 1/2 of an ibuprofen PM to sleep fo a long time....when I took a whole tablet I woke up groggy ( like drunk)
My doc prescribed Valium, it worked, but it's addictive. I stopped, since my gene study shows its not the best for me.
I now have an Rx for clonazepan, but only take it when I have extreme anxiety, and then 1/2 of 5 mg. tab.
It works, however I do not want to be totally dependent on this.
I am back to ibuprofen PM most of the time.

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Is your prescribing doctor a Psychiatrist? I would definitely see them and sounds like some therapy may be helpful

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