How long do Lupron side effects last after treatment concludes?

As the ADT left my system and my testosterone levels returned to normal, the few side-effects that I did experience - warm flashes, zero libido, & muscle atrophy - all subsided.

I recall telling my wife that I thought the Eligard was wearing off because I was beginning to lift heavier weights at the gym. Since I wasn’t due for another “official” PSA test for another couple of months, I self-ordered another PSA & testosterone test, and those came back as 0.13 & 403.0, respectively, showing everything was going exactly as expected - that is, PSA staying low and testosterone increasing as the ADT was leaving my system. The muscles and strength all slowly returned.

I immediately began having a side effect apparently no one else ever experienced. Every single time a hot flash was about to come on I first experienced leg pain from the knees down lasted 3-4 minutes when gone the hot flash came on. Happened 10-15 times a day and night. I spoke to several Dr about this no one had anything to say. After one year of full dose of lupron every 6 months we tried half dose every 3 months the number of time reduced slightly did not go away. Did that for year 2 then switched to Rugolix pill for the year 3. Finished that in December. Still experiencing the leg pain 10-15 times day and night. The other side effect was insomnia pulmanary Dr tried 5 different sleep pills none of which offered any relief. Average sleep time now is 2.7 hours a night not continuous. I fear this is a way of life for me now.

@dillon5520
There are solutions for the hot flashes. My oncologist prescribed a depo-provera Shot every three months and it stopped my hot flashes almost completely. I was getting really severe ones multiple times a day and they would start off with a lot of fatigue and then the hot flash.

Some people have found that Acupuncture actually works to stop the hot flashes and it has to be done a few times before it becomes effective.

One of the Mayo doctors posted this information on drugs you can take to stop the hot flashes. Oxybutynin is included in the list and I’ve heard from people that have been using it and found it to be very helpful. Gabapentin has helped some people, but I’ve been on a lot of it for many years and don’t find it helps at all. Different people have different results.

Another thing you can do is get estradiol patches. You only need one patch and you can try different strengths, but it’s supposed to make a major difference in hot flashes.