side effects after going off Lupron

Lupron effects including the ones you mention are due to its suppression of testosterone. You can expect to have those effects until your testosterone returns which usually takes 6 months and can be up to a year AFTER the expiration of the shot. In effect you are still on Lupron and in the process of getting off and will be for many months.

As your testosterone level returns to normal, you will have increased sexual interest.

My brother had a six-month Lupron shot When he had SBRT radiation. It took almost a year before things went back to normal. He was 77. Hot flashes lasted about nine months after the shot’s Give it five more minutes

The heroe study showed that testosterone comes back after about five months. A lot of it depends on age.

Here’s a link to the study
https://www.sciencedirect.com/science/article/pii/S2588931123002900

As the ADT left my system and my testosterone levels returned to normal, the few side-effects that I did experience - warm flashes, zero libido, & muscle atrophy - all subsided.

I recall telling my wife that I thought the Eligard was wearing off because I was beginning to lift heavier weights at the gym. Since I wasn’t due for another “official” PSA test for another couple of months, I self-ordered another PSA & testosterone test, and those came back as 0.13 & 403.0, respectively, showing everything was going exactly as expected - that is, PSA staying low and testosterone increasing as the ADT was leaving my system. The muscles and strength all slowly returned.