Does anyone have experience taking the antipsychotic Latuda?

@kelster69 You were diagnosed with Major Depressive Disorder and given Latuda for your depressive symptoms but you think you may have bipolar disorder. Did I get that right? You want to connect with members that have experience with Latuda.

Below I have linked a recent discussion related to Bipolar Disorder.
- Bipolar forum https://connect.mayoclinic.org/discussion/bipolar-forum/

Members like @hopalongnm3 @tooleyb are both new members that have posted in the bipolar forum.

Members @bustrbrwn22 @douglasebaker @brijeshmishra have discussed medications that treat depression.

You said that you feel you may have bipolar. I assume your depression has a high severity. Would you tell me a little more about that and what you have tried in the past regarding medications, treatment, etc.?

Hello, @erikas , thank you for getting back to me so soon. I've been diagnosed with MDD much of my life, and it's been worse over this past year. My dad was diagnosed with bipolar disorder at 62. I am 51, have had some very stressful things happen over the past couple of years, and I'm not sure which type of bipolar I may be, if at all. My psychiatrist said that I have bipolar GENES, but not necessarily a diagnosis. I've been on 40 mg. of Prozac for a few years (went off it completely last year, what a mistake), am also on .5mg Klonopin morning and night, and 300 mg. Gabapentin in the morning. I tried lamotrigine for 3 days and it made me suicidal (as did Pristiq, which I tried at the beginning of December). So my psychiatrist told me to start 10 mg. of Latuda starting today. I feel a bit better tonight, but it might just be because I usually feel better at night.
And yes, my depression has a high severity, especially over the past year. The past few weeks, I've had some good days, followed by very bad ones, or one up and one down. I've tried ketamine (86 treatments in total; it worked in the beginning but in the end I think it made me worse), TMS, scopolamine, DBT, am in therapy with my psychiatrist 2x/week. I've also tried most SSRis (Prozac worked but then stopped, the 40 mg. helped a bit), take L-Methylfolate, have tried other antipsychotics, Lithium, Effexor, and the others I've named above.
Thanks in advance for reaching out. I feel like a walking pharmacy as well as a lab rat.
-Kelley

I have hard to treat MDD. I take Duloxetine 60mg 2 per day plus Bupropion XL 300mg. I began taking Latuda three years ago. I felt great, no side effects. At the time there was no generic so it was very expensive. My doctor sent a prescription to a pharmacy in Canada, where they had generic. The price was much lower. I took it for about six months. Then the FSA confiscated my drugs. I kept thinking "they will be here any day now". After being off Latuda for about three weeks, I paid full price for a prescription and started taking them again. This time, after about three weeks I was having horrible side effects (very bad depression and completely unable to fall asleep, very agitated) so I stopped taking them. I have not found anything else that works. My doctor thinks it may have been something else that caused the bad reactions, so today I will start taking the lowest dose of Latuda, praying and keeping my fingers crossed that this time I don't have any of the same reactions as last time. Has anyone else had similar problems with Latuda?

I start the same medication as well, not bad, I’m bipolar too. How bad you feel?

I’ve been on lurasidone since Nov 2024. It’s helped my depression a lot now that I’m up to 60 mg/day. However, the last few weeks, I’ve had some panic attacks in the evening, about 1.5-2 hours after taking it. I’ve upped my Buspar to 15-15-15 each day and that has helped, but the fear still strongly rises. Last night something happened that was unexpected. I took lurasidone about 2.5 hrs late, and the fear did not come upon me until about an hour after I took it. So, I’m thinking I need to reduce my lurasidone dosage to 40 mg to help the panic. Does this make sense? What is your experience with lurasidone and fear or panic? Thanks.

I know nothing about this medication. I do know psychotrophic meds can have adverse reactions including anxiety fear insomnia depression etc. Do you have a provider who can help you with these issues?

Yes, I have a psychiatrist.

@kelster69 how did TMS work for you? And how has the latuda been going?