Lamictal and HRT

Posted by minajo @minajo, 8 hours ago

My nonverbal autistic, epileptic daughter has been on Lamictal XR for about two years , she's had sigmoidectomy, long recovery two years ago, and just turned 50,She has many behavioral issues, on Seroquel which after 10 years we just started reducing by 25 mg as her EKG was borderline,( seems Seroquel causes qt issues) pcp has had her on lowest dose progesterone for several years to stop periods( her personal care issues) but just started Estrace , lowest dose estrogen to try to avoid menopause issues , just started 4 days ago , then I read Lamictal and estrogen could affect seizure threshold
No reply from PCP or neurologist yet but I can't do another drug change with her seizure med( just got her off zonisamide two years ago)
She's so very complex now, really thought low dose estrogen could help her severe insomnia, maybe even bizarre behaviors
Just wondering if anyone has used Lamictal and hrt? Even getting labs done hard, Lamictal gets sent out too, takes over week for levels!
Thoughts greatly appreciated
Lisa's mom

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Jake | @jakedduck1 | 4 hours ago

@minajo
Estrogen breaks down Lamictal, similar to how Dilantin and other drugs accelerates the metabolism of Vitamin D.
Has the doctor recommend a higher dose or other changes?
The estrogen may cause a significant reduction in the Lamictal lowering the seizure threshold.
Are your daughter's seizures controlled?
Ask the doctor for a Lamictal level within 7-10 days.
Blessings to your daughter & family,
Jake

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