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Lynsorensen
@lynsorensen

Posts: 15
Joined: May 18, 2017

Kappa Light Chains and PN

Posted by @lynsorensen, Jul 25, 2017

Anyone else been tested for Kappa and Lambda light chins free serum in connection with peripheral neuropathy?

REPLY

LOL I mean light CHAINS, not chins

Hello @lynsorensen, I have not heard of kappa light chains before but did find some information from Mayo Clinic’s News Network:

http://newsnetwork.mayoclinic.org/discussion/mayo-clinic-ids-immune-system-glitch-tied-to-fourfold-higher-likelihood-of-death/

I also did a search on Google Scholar (https://scholar.google.com/) using the search term “kappa light chains cause neuropathy” and it found quite a bit of information:

https://scholar.google.com/scholar?as_ylo=2017&q=kappa+light+chains+cause+neuropathy&hl=en&as_sdt=0,24

Hope this helps, also that others jump in the conversation if they have more information.

John

@lynsorensen are you able to share a little more about your neuropathy? Do your doctors/neurologist suspect kappa or lambda light chains free serum as the cause of your neuropathy.? Also did they give a specific diagnosis for your neuropathy?

Hopefully we can help you find the information you are looking for…

John

@johnbishop

@lynsorensen are you able to share a little more about your neuropathy? Do your doctors/neurologist suspect kappa or lambda light chains free serum as the cause of your neuropathy.? Also did they give a specific diagnosis for your neuropathy?

Hopefully we can help you find the information you are looking for…

John

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The latest (of 5) neurologists took a long shot and tested me for amyloidosis as the source of my peripheral neuropathy.  Tested for it twice, 3 months apart, and came back positive for kappa light chains free serum which is usually an indicator of multiple myeloma or amyloidosis as the cause of peripheral neuropathy.  It is unusual for doctors to think of testing for this that it usually goes undiagnosed until too far progressed for treatment to be effective.  I am on my way  now to the hematologist at Mayo Clinic for the tests that will need to be done next (fat pad biopsy and possible bone marrow).  If those tests also come back positive for amyloid deposits, it will then be discussed if I can be selected for the stem cell and chemo treatment to stop the progression of the disease.

@johnbishop

@lynsorensen are you able to share a little more about your neuropathy? Do your doctors/neurologist suspect kappa or lambda light chains free serum as the cause of your neuropathy.? Also did they give a specific diagnosis for your neuropathy?

Hopefully we can help you find the information you are looking for…

John

Jump to this post

Thank you for sharing the additional info. Sounds like you really have a great team of neurologists and they have a plan in place. So much we don’t know about the different causes of neuropathy. This is really helpful information.

Thanks again….John

I am going to ask my Neurologist about being tested. He had recommended that we do bio marker testing for like RA and some others since I am positive for the FGFR3 ANTIBODY.
Thank you for the mention of this.
Darlia

Yep.

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