Jardiance for stage 3a CKD or Acute Kidney Injury (AKI)

If you're asking about SGLT2 inhibitors (sodium-glucose co-transporter 2 inhibitors), they are a class of prescription medications primarily used to treat type 2 diabetes, and more recently for heart failure and chronic kidney disease (CKD). I take Jardiance and tolerate it well.

SLGT-2 medicines are mainly for those with type 2 diabetes, but also useful for CKD and AKI (and those of us that don't tolerate ACE meds like Lisinopril). It can have cardiovascular (CV) benefits, such as lowering blood pressure and decreasing creatinine levels, and slightly decreasing weight. My CV system is fine, but my nephrologist prescribed Jardiance both for kidney function and to decrease the risk of CV damage, which is a common result from kidney disease. Most common side effects are dehydration (drink more water), UTIs, and yeast infections from increased sugar in urine (clean well "down there). https://www.drugs.com/drug-class/sglt-2-inhibitors.html https://www.kidney.org/kidney-topics/sglt2-inhibitors https://www.sciencedirect.com/science/article/pii/S2452302X20300759

@loriel Welcome to Mayo Clinic Connect! You have seen two good responses from @howardrlewis and @kayabbott, so no need for me to add to their words...

Are you a chronic kidney disease patient? If so, what stage are you in now? Any questions for me?
Ginger

Unfortunately, every doctor I have been to and also physical therapists say Kegels do not affect urinary incontinence. Mine is now severe, which is why I am in heavy-duty diapers 24/7. Mine started with delivering 3 children, 2 of whom were over 9lbs, and one of them was a full transverse. The Septic Shock did me in for sure. Even having a nerve stimulator won't help me.

Sorry the pelvic PT didn't work for you. Incontinence is very hard to live with, especially following septic shock and prolapse and other stresses from delivery. Pelvic floor exercises were prescribed for me after a bike injury hygroma, and for my husband following prostate surgery. The exercises have worked for us, but our stresses have been less and the incontinence was minimal. BTW, my sports medicine doctor wasn't very good, so we found a gynecologist with sports background who was great. I call her my sports medicine gynecologist. At least those doctors are familiar with women's issues, muscle groups, and such "down there."

I appreciate the replies! I’m just beginning this journey. Last week at a wellness check my GP informed me I have Stage 3 Kidney failure. Really surprised me since I wasn’t told anything during Stage 1-2. She suggested Farxiga, but I want to learn more. Don’t have diabetes but take meds for BP and it’s controlled. I’m 66 and feel quite well.
I left a message for Dr requesting a referral to a Nephrologist, but haven’t heard back yet.
Was anyone else apprehensive about starting these meds?

Farxiga is a SLGT-2 medicine for CKD, Type 2 diabetes, and heart disease. My nephrologist prescribed 10 mg/d Jardiance) for acute kidney injury and/or stage 3a CKD). I've only been on it a week and no side effects. This link will give some background info on the drug. https://www.drugs.com/farxiga.html Most common side effects are peeing more and risk of UTI and yeast infections. Included are drug and reviews (negative are mostly from UTI and yeast). Absolutely see a nephrologist. Stage 3a is mostly drink enough water and avoid dehydration. With stage 3b the dietary changes ramp up, controlling salts/sugars/simple carbs, decreasing foods high in potassium and phosphorus, and others. If you are at 3b then it would be good to talk with a nutritionist knowledgeable about kidney diseases/injury. Check also on if your insurance covers it (some SLGT-2 meds are covered, others less so). Here is a very boring research paper on the med: https://www.ncbi.nlm.nih.gov/books/NBK538721/ . ACE 2 meds are sometimes prescribed for CKD as well; even tho they are heart meds, they decrease protein levels which has a protective effect on kidneys. https://www.mayoclinic.org/diseases-conditions/high-blood-pressure/in-depth/ace-inhibitors/art-20047480

Looks like helpful info, thank you! I’ll look into it. So encouraging to hear you are feeling okay taking it so far. I need to investigate our insurance coverage for Farxiga.
Advice about getting a nutritionist knowledgeable about kidney issues is appreciated too!

At 70 I experienced kidney stone 12 yrs ago and never since. Now I have passed 2 stones, extreme discomfort and tire easily, and after 2 CT, I still have a pretty large stone in the kidney. Pain is limited in kidney. Still walk dogs 3+ miles a day. How long can stones stay there? Urologist has been talking surgery since the first time I met him. I am not a surgery person and would like to get more info on blasting stones. Also do I need to find a nephrologist instead of a urologist? An

I doubt the stones dissolve on their own. Urologists generally treat kidney stones. Nephrologists are more for kidney diseases such as diabetes, CKD, AKI, etc. My husband had a stone a few years ago and there was not surgery even tho it was large. Generally they are blasted with sonic waves and the pieces are sucked out; any remaining small particles are expelled with urine. He drinks more water now (dehydration is a factor in stones) and also drinks citrus (also helps to prevent them). https://www.niddk.nih.gov/health-information/urologic-diseases/kidney-stones/treatment https://my.clevelandclinic.org/health/diseases/15604-kidney-stones