1. < Autoimmune Diseases

is there such a thing as zero negative Sjogren’s?

Posted by lsk246 @lsk246, Jan 9 12:41pm

Can a person test negative for Sjogren’s and still have the disease? my sister has zero negative polyarthralgia and severe dry mouth. I’ve long suspected Sjogren’s but she tests negative. What else could it be?

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megangreen | @megangreen | Jan 20 9:36pm
In reply to @dloos "I have dry eyes, nose, mouth, skin. I am dizzy and my hearing is distorted with..." + (show)
@dloos

I have dry eyes, nose, mouth, skin. I am dizzy and my hearing is distorted with tinnitus and hyperacusis. I have tested negative three times for Sjogrens. Since having Covid, all these issues are much worse. I do not have pain, except for gritty uncomfortable, light sensitive eyes.
I do wonder if I have not yet had the right test.

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I am sorry dloos that you have all these symptoms with as yet, no resolution.

As a few of us have said, a negative Sjögren’s test does not necessarily mean that you do not have SS. It has been found that quite a significant percentage of ‘sufferers’ remain seronegative for some time or forever. These estimates are based on individual studies which range from 15% to something like 48% seronegative. However when these ‘Sjögren suspicious’ patients are clinically examined by a specialist Rheumatologist many can be fairly reliably diagnosed based on symptoms and other parameters.

Did you have a lip biopsy done or blood testing?

If you enjoy reading medical article abstracts there are quite a number of them accessible online which provide information and data on this topic of SS seronegativity.

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dloos | @dloos | Jan 21 10:31am
In reply to @megangreen "I am sorry dloos that you have all these symptoms with as yet, no resolution. As..." + (show)
@megangreen

I am sorry dloos that you have all these symptoms with as yet, no resolution.

As a few of us have said, a negative Sjögren’s test does not necessarily mean that you do not have SS. It has been found that quite a significant percentage of ‘sufferers’ remain seronegative for some time or forever. These estimates are based on individual studies which range from 15% to something like 48% seronegative. However when these ‘Sjögren suspicious’ patients are clinically examined by a specialist Rheumatologist many can be fairly reliably diagnosed based on symptoms and other parameters.

Did you have a lip biopsy done or blood testing?

If you enjoy reading medical article abstracts there are quite a number of them accessible online which provide information and data on this topic of SS seronegativity.

Jump to this post

I’ve had three blood tests. I was told definitively “not Sjogrens”. Thank you for the information. I do feel all I do is read medical studies!
I will ask my doctor about a referral to a rheumatologist.

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