Is it Waldenstrom Macroglobulinemia?

Posted by barbarian1 @barbarian1, 1 day ago

Here are the results from my bone marrow biopsy. Has anyone else had similar results for this diagnosis?

Low-grade B-cell lymphoma, see note

Note: Immunohistochemical profile and the history of IgM kappa monoclonal gammopathy favor diagnosis of lymphoplasmacytic lymphoma/immuno cytoma (Waldenström's macroglobulinemia)
Positive for MYD88 L265P mutation
Flow cytometry - Diagnosis: Consistent with CD10-positive B-cell lymphoproliferative disorder admixed with a small monoclonal kappa restricted plasma cells. Comments: Flow cytometry shows monoclonal B-cells (2.8% of total cells) with dim CD10 expression without CD5 or CD11c, consistent with a CD10-positive B-cell lymphoproliferative disorder. The main differential diagnosis includes atypical lymphoplasmacytic lymphoma, follicular lymphoma, Burkitt lymphoma and large B-cell lymphoma. Although a large B-cell lymphoma cannot be excluded based on flow cytometry alone, the flow cytometry revealed primarily small lymphocytes. Please correlate the result with morphologic findings and clinical information. Flow Differential (%) and Population Analysis: Lymphocytes: 32.2% T-cells (69% of lymphoid cells) show a CD4:CD8 ratio of 1.1 without overt phenotypic abnormality. NK-cells (20% of lymphoid cells) are unremarkable. Mature B-cells (9% of lymphoid cells) are small in size based on the forward scatter pattern and show: CD5 neg, CD10+,(subset), CD19+, CD20+, with surface kappa light chain restriction (kappa:lambda 19.3)

Based upon these findings, with IgM clonal protein and MYD88 mutation, this fits with this type of lymphoma.
This lymphoma will not go away, but can be treated if starting to cause symptoms or getting too high on your IgM level.
We will talk about doing some CT scans to see if lymph nodes enlarged as well.
Hope that this helps.

Interested in more discussions like this? Go to the Blood Cancers & Disorders Support Group.

Sure looks like WM. I follow a WM group on Facebook. You also might want to signup with https://iwmf.com/ They have a huge amount of data and research going on. Good luck.

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Attended my first IWMF educational forum as a virtual attendee. Very helpful since I have been diagnosed with Waldenstrom’s and Polycythemia Vera and am not well enough to travel. I experience fatigue, dizziness, shortness of breath, and edema. Currently on Hydrea twice weekly and phlebotomy twice a mont for PV. Watch & Wait for WM. May begin 6 months of BR shortly. Getting second opinion was very helpful, but costly. Am 73 years old, female, diagnosed in 2024 after 7 years of various symptoms. Important to be your own best advocate since I was constantly told there was nothing wrong even when my blood results said otherwise. Condition may be too rare for some doctors to recognize it as in my case.

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