Is a Spiculated lung nodule always malignant?

Posted by darwin66 @darwin66, May 16, 2023

Hello,
58M, Nonsmoker, No history of cancer
I went to a pulmonologist due to coughing, shortness of breath for over 2 years and got diagnosed with allergic asthma.
Ct scan showed 5 lung nodules all on the right lung.
2 are calcified -most likely granuloma,
2 perifissual- which are most likely benign
1 subpleural nodule 5mm
1 spiculated nodule 5mm
The spiculated lung nodule worries me the most
I did research and all data and studies say that spiculated nodules are malignant with a predictive value of up to 90% ..
Doctor wants to just monitor it with follow up Ct scans.
I read that in rare cases infections, Inflammation or sarcoidosis can have Spiculation but Generally such nodules are a sure sign of Malignancy.
Anoyone on here who has experience ?

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Keep me posted on how you are doing and if you have any other concerns. I will try to help as I can. A lung cancer diagnosis was very, very scary years ago but with all the progress that has been made in treatment possibilities, I think we should have a more positive outlook.

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Profile picture for macallan @macallan

I am glad you have a plan. I had five treatments 20 minutes each. But a friend of mine had ten treatments ten minutes each. I had no stomach issues..just some fatigue which would just hit me so I took a nap. I arrived about 15 minutes early and they took me right on time. I was in and out in 30 minutes. At the first appointment they do marking… you lie on something that moulds to your body and they mark your body with a marker pen and cover it with special tape so that they can put you in the correct same position each time. Then the following visit is your first treatment visit. it is absolutely painless and I had to remain very still. I was able to choose music to listen to which made the time go quickly. You can drive yourself or have someone else drive you but if you bring someone they cannot be in the room with you. The radiologist doctor met me a couple of times after a treatment. He then has rescheduled me for a PET scan 2 and 1/2 months after I finished treatment to see if the tumor has broken up and how my lungs look. They have had very good success with SBRT and I think this is the “to go” procedure for elderly people who cannot have a biopsy or surgery.. I have had no side effects from the treatments except for some fatigue. They have had time will go by quickly once you start treatment. I will be thinking of you.

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Thank you so much for your detailed & comprehensive reply. It helps me to anticipate what lies ahead with greater peace of mind.
Thank you again!

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Profile picture for Lisa, Volunteer Mentor @lls8000

Hello @democrite, every case is different, so we aren't able to say if this biopsy is warranted or not. You didn't mention how large the nodule/mass is believed to be. A biopsy can be performed for more than a yes/no decision on if this is cancer. A biopsy has the potential to determine what type of cells are contained in the nodule or mass, and based on that, the doctors can determine if further treatment is necessary, and the best course of treatment.
The opinion of another pulmonologist will help you to make a decision on the biopsy.
The PET didn't show uptake/light at all? That's good news! You may want to ask the pulmonologist about the potential for infection, and wouldn't an infection light up on the PET too, just at a lower rate? You are questioning the need for the biopsy. Some people would need to know what the nodule is right away, while others would be comfortable waiting and re-scanning. We all get to make decisions about our comfort levels; comfort with waiting, comfort with procedures, etc. Doctors make recommendations, but ultimately, we get to make the final decisions. Wishing you well!

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Hi Lisa,

Thank you for your kind and professional response.
-Nodule is 1.4x1.4, mildly spiculated
-was 1.2X 0.8 during last scan like 5 months ago
-Lightly spiculated
French pulmonologist was absolutely categoric it should not be biopsied but antibiotic for a month then repeat a scan
-Biopsy was ordered by thoracic surgeon
-Important detail, the CT scan who shows the nodule growth was done 15ish days after i return from a long trip in Thailand, lot of ppl were sick in the plane and i got sick, like really sick, coughing like crazy for 2 weeks after i returned.
-i explain this to the surgeon who booked the biopsy and he did not react
- Personal research and talk with French pulmonologist show it is a relevant information who could/might have oriented in a different direction than biopsy since risks of infection in this part of the world are a real thing.
- I will see another pulmonologist in the US this Friday...
Voila...
Best and thank you

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My neuroendocrine tumor was coincidentally discovered when an x-ray looking for something else showed a mass in my right lung with spiculation. Biopsy and PET scan confirmed it was an NET in the middle lobe and also a cancerous lymph node in the upper lobe. The middle lobe and bottom part of the top lobe were removed with robot-assisted surgery. It’s three and a half months later, and I am feeling close to fully recovered and hoping the six month scan will find nothing but good news.

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Profile picture for celeste46 @celeste46

My neuroendocrine tumor was coincidentally discovered when an x-ray looking for something else showed a mass in my right lung with spiculation. Biopsy and PET scan confirmed it was an NET in the middle lobe and also a cancerous lymph node in the upper lobe. The middle lobe and bottom part of the top lobe were removed with robot-assisted surgery. It’s three and a half months later, and I am feeling close to fully recovered and hoping the six month scan will find nothing but good news.

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Hello @celeste46, I'm glad to hear that you are feeling well three months post-surgery. That will give others hope too.
In case you haven't found it, there is a NET group also: https://connect.mayoclinic.org/group/neuroendocrine-tumors-nets/
Hoping your next scan goes well!

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Hello. Yes. I have had same experience.
I had CT scan... 15 months later another scan. It shows a 7mm spiculated nodule that was not there before and radiology seemed concerned. I have been diagnosed 17 months ago by have a test. I got in glass box and panted haha. I'm 54 and surprisingly had no clue as to what I was doing or why. 2 months after test the finally admitted mind you I worked 2 months with me saying to doctors I AM SICK. I assumed it was bronchitis. They say I have COPD with unspecified emphasema. ( My latest CT say no emphasema no bronchitis) I use 2 puffers 4 times a day. My lung "specialists" sent me a note in my portal saying..." I believe this 7mm spiculated nodule is due to infection. I will do another CT scan and see you Sept 19. I'm not sure what infection I have and wouldn't that need rest and antibiotics? I've been working a very strenuous job that requires approximately 15 trips up and down stairs. So maybe yours is a infection that will just heal itself. I also take ibuprofen. 800 mg 2 times daily. Generic OTC I'm hoping for healing.

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Profile picture for Maria @maroa

Hello. Yes. I have had same experience.
I had CT scan... 15 months later another scan. It shows a 7mm spiculated nodule that was not there before and radiology seemed concerned. I have been diagnosed 17 months ago by have a test. I got in glass box and panted haha. I'm 54 and surprisingly had no clue as to what I was doing or why. 2 months after test the finally admitted mind you I worked 2 months with me saying to doctors I AM SICK. I assumed it was bronchitis. They say I have COPD with unspecified emphasema. ( My latest CT say no emphasema no bronchitis) I use 2 puffers 4 times a day. My lung "specialists" sent me a note in my portal saying..." I believe this 7mm spiculated nodule is due to infection. I will do another CT scan and see you Sept 19. I'm not sure what infection I have and wouldn't that need rest and antibiotics? I've been working a very strenuous job that requires approximately 15 trips up and down stairs. So maybe yours is a infection that will just heal itself. I also take ibuprofen. 800 mg 2 times daily. Generic OTC I'm hoping for healing.

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Sorry for some of the typos. I'm on my cell phone and I'm southern

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Profile picture for alicedavis @alicedavis

I would insist on surgery!I am having a biopsy and my nodule
Has some spikes on the top?

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Hello @alicedavis, I'm sorry that you're facing this. Has your biopsy been scheduled? Do you have any results yet?

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Profile picture for Lisa, Volunteer Mentor @lls8000

Hello @milana, I'm sorry to hear that you are facing this issue, it's never an easy thing to go through. Nodules are rightfully concerning, but they are usually not cancerous.
I'm not a clinician, just a lung cancer patient.
For reference, my first PET showed an SUV over 10. We knew it was cancerous, and that was confirmed by a biopsy. A later PET of a different nodule showed a much lower SUV, and it was not cancer, it was a fungus in my lung, also confirmed through biopsy.
Did you see a pulmonologist? Did they discuss doing a biopsy prior to surgery?

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Hi, I saw a pulmonologist , and they recommend robotic surgery: to remove the nodule, do the fast test while operation is going on ,and then if cancer confirmed remove the lobe and lymph nodes. This surgeon is saying that he can not rule non cancer, due to the low SUV of 2.1 I also saw a specialist in a cancer clinic, she referred me to a surgeon, who also said surgery....she even talked to me about treatment plans after surgery, depending of the type of cancer. So now I need to make a choice which hospital to go to, as they both recommend surgery; difference is that one says your low SUV is on the limit of cancer ir non-cancer , versus the oncologist ( who is obviously dealing with cases like mine on a daily basis) who didn't doubt my cancer. Thanks for reaching out to me !!! Appreciate it

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Profile picture for Lisa, Volunteer Mentor @lls8000

Hello @milana, I'm sorry to hear that you are facing this issue, it's never an easy thing to go through. Nodules are rightfully concerning, but they are usually not cancerous.
I'm not a clinician, just a lung cancer patient.
For reference, my first PET showed an SUV over 10. We knew it was cancerous, and that was confirmed by a biopsy. A later PET of a different nodule showed a much lower SUV, and it was not cancer, it was a fungus in my lung, also confirmed through biopsy.
Did you see a pulmonologist? Did they discuss doing a biopsy prior to surgery?

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What was the SUVmax for the non cancer nodule ?

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