Implications of Long Term Drug Regime

Posted by jcaesar @jcaesar, Jun 19, 2025

My wife has protruding discs in her vertebrae which result in chronic severe pain in her legs to the extent that she is unable to sleep for most nights. The solution is surgical but this being Canada, that is at least a year off. The physician has prescribed -
Tylenol 3 - to be taken 4X / day
Naproxen 250mg - to be taken 2X / day
on an ongoing indefinite basis. So with the prospect of being on this regime for at least a year or so, the following questions arise -

can the kidneys / liver safely handle this regime for a year?

does tolerance to the codeine kick in after a few months, minimizing its potency?

can the severe constipation that results from the opiod be handled with a fibre rich diet alone or are laxatives required?

Interested in more discussions like this? Go to the Chronic Pain Support Group.

You need to keep in mind that we are all different and drugs work differently on everyone. Nothing is a wonder drug and I usually ignore things that are that carry that label. It’s unfortunate that your wife has to suffer like this but it happens like that here in the states sometimes too. Since laying on her back is problematic I hope she can walk which should be one of her prime exercises for her GI system to help it function properly despite the meds. I’ve been on some type of narcotic since 1988 when I broke my back in a fall during a small California earthquake and my system and body functions are fine. There are many of us chronic pain sufferers on this forum who’ve been in a similar situation. I wish you and your wife good luck.

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