I have been doing a lot of research on this disease Osteoporosis

Posted by linders @linders, Sep 7 1:39pm

Has anyone here tried Bone Restore Trifecta I have been on supplements for 6 bones and don’t feel I am getting anywhere my doctor is so slow to referring me to a spine specialist
I have a few fractures in my spine and I need it looked at!

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loriesco, I see the disconnect. I meant to say that people with osteoporosis and osteoarthritis are unlinked in ratio. I must have accidentally written osteoarthritis and hip arthritis aren't linked. I'll correct my post when I on that account when have access to it. Hip arthritis doesn't lead to osteoporosis. They are completely different diseases. There is overlap because both are age related. Even so the percentage are low. I haven't seen causation in the medical literature.

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Profile picture for sharonba @sharonba

A word of caution about relying on research studies more than 5 years ago. Medical research is usually 2-3 years behind by the time of its publication date. The rule of thumb is not to cite research that is more than 5 years old. Regarding a negative association between osteoarthritis and osteoporosis there is more current literature that challenges that assumption by gender specific studies. Contemporary research demonstrates these conditions in men are non-linear and lean heavily on diagnostic parameters. The studies demonstrate a shifting from a positive association in mild disease to a high co-occurrence of OP in end stage severe OA. Studies can be found on PubMed Central.

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@sharonba ok but that eliminates all the clinical trials for all the drugs we are taking for osteoporosis. There may be one a half year left on Evenity.

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Profile picture for gently @gently

@sharonba ok but that eliminates all the clinical trials for all the drugs we are taking for osteoporosis. There may be one a half year left on Evenity.

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@gently Clinical trials that have shown medication efficacy are different. If a medication has had a successful clinical trial and approved by the FDA and subsequently prescribed to patients with good outcomes, there is no need to continue research on that particular medication. There are always new ongoing studies with other osteoporosis medications and would recommend discussing those with your provider.

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Sometimes new evidence brings into question the published material we reference. Age alone doesn't invalidate the information in research. Links following current research evidence the value of published data decades old.
Successful clinical trials and approval by the FDA doesn't eliminate the need for further research on any medication.
Prolia for example approved in 2010. Incidentally (the incidents being cascade vertebral fractures) was discovered to cause profound rebound, not until 2017. In 2022 a new warning was issued after discovery (by death) of hypocalcemia in patients with severe kidney disease.
It is good to discuss things with your medical providers. If you want information about ongoing studies for new osteoporosis medications it's best to look at publications like Science Daily or Science Digest then track the lab and the lead researcher. It wouldn't be fair to expect your provider to know about possible future medications.

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Hi Everyone, I didn't see mention of REMS - "Radiofrequency Echographic Multi-Spectrometry, a technology used to assess bone density and quality without radiation. It provides insights into bone health by evaluating both mineral density and the internal structure of bones."
This is a totally different test and considered superior to DEXA - why? because unless you get test on the same DEXA machine each time, results may not be accurate. DEXA machines are made by different companies. REMS machines are made by the same company. You get a far more accurate test result to compare from test to test dates. I have now done this twice and it showed where my metrics stayed stable, improved or declined some.
You will need to search to see if REMS is available in your area. I personally am inpressed. One metric added is percentage of likely bone fracture.
Another test which I have not done yet and recently learned about is to have my bone markers tested - bone markers look at the break down and build up of bone.
Best to everyone dealing with osteoporosis or osteopenia and trying to prevent fractures or breaks.

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