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Husband’s low psa, aggressive Gleason 8

Posted by gemini27 @gemini27, Jul 11 8:35pm

I’ve been reading along here for a while. Many knowledgeable people! My husband (just turned 60) was diagnosed Jan Gleason 8, pni, large tumor volume, probable invasion into capsule (but no confirmed epe). PSMA pet no spread.
Took firmagon one month then began eligard. Radiation 28 sessions completed in April. Psa at diagnosis 2.6. Took a baseline psa in Feb before starting adt- 1.9. Took psa after one month of firmagon (prior to rad.) and it was 1.1. Decipher .94 Will get first psa in a couple weeks. Not sure what to expect as far as psa. I believe they said his threshold will be lower.
Any thoughts welcomed!

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vircet | @vircet | Jul 25 5:14pm
In reply to @gemini27 "Thanks for all of the input. First Psa (3 months post RT and 4 months on..." + (show)
Profile picture for gemini27 @gemini27

Thanks for all of the input. First Psa (3 months post RT and 4 months on ADT), came back < 0.1, testosterone 22. So far so good 🙂

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What ADT are you on? (I'm on Orgovyx 4 months and 3 months post SBRT.) It looks like you have better results. What was your PSA before RT? (I was 10.5 down to 0.36 two mos. & 18 days post-radiation.) Congrats for your better than good results.

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jeff Marchi | @jeffmarc | Jul 25 5:38pm
In reply to @pjsatz "Does the study say anything about whether the 4 years, 5% applies if on adt +..." + (show)
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Does the study say anything about whether the 4 years, 5% applies if on adt + lutamide or could the time period or probability be different?

Thank you,

Phil

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I was told it applies to ADT and ARSI drugs. They didn’t get to the point of testing it with different versions of drugs.

I think it was at ASCO last year where they discussed this neuroendocrine issue. Len over at Ancan.org discussed this after the conference.

Maybe an AI can tell you more.

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vircet | @vircet | Jul 25 7:21pm
In reply to @gemini27 "Thanks for all of the input. First Psa (3 months post RT and 4 months on..." + (show)
Profile picture for gemini27 @gemini27

Thanks for all of the input. First Psa (3 months post RT and 4 months on ADT), came back < 0.1, testosterone 22. So far so good 🙂

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@gemini27 On the other hand, my testosterone dropped to "0.4", lower than your "22".
@jeffmarc You indicated in another discussion thread that the PSA is expected to drop to < 0.1 within 6 months. My PSA dropped from 10.5 to 0.36 after 3-1/2 months, I'm a bit worried if I will hit < 0.1 on my next PSA.
Has anyone had 0.36 or higher on their first PSA after radiation and did well on the second PSA test?
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jeff Marchi | @jeffmarc | Jul 25 7:59pm
In reply to @vircet "@gemini27 On the other hand, my testosterone dropped to "0.4", lower than your "22". @jeffmarc You..." + (show)
Profile picture for vircet @vircet

@gemini27 On the other hand, my testosterone dropped to "0.4", lower than your "22".
@jeffmarc You indicated in another discussion thread that the PSA is expected to drop to < 0.1 within 6 months. My PSA dropped from 10.5 to 0.36 after 3-1/2 months, I'm a bit worried if I will hit < 0.1 on my next PSA.
Has anyone had 0.36 or higher on their first PSA after radiation and did well on the second PSA test?

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The rule for radiation is very different from the rule for surgery.

If you have radiation, it can take years for your PSA to come to the minimum because cells are dying off at different rates. Even if on ADT. Some people’s cancer dies quickly.

I’m sorry if I misinformed you, not realizing you only had radiation.

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gemini27 | @gemini27 | Jul 27 2:32pm
In reply to @vircet "What ADT are you on? (I'm on Orgovyx 4 months and 3 months post SBRT.) It..." + (show)
Profile picture for vircet @vircet

What ADT are you on? (I'm on Orgovyx 4 months and 3 months post SBRT.) It looks like you have better results. What was your PSA before RT? (I was 10.5 down to 0.36 two mos. & 18 days post-radiation.) Congrats for your better than good results.

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Hi, actually the wife here🙂 He did one month of Firmagon to drop quickly then on Eligard. 1.9 psa before radiation. 3 mo after radiation (and 4 mo on hormones), psa < 0.1.

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