How to treat hands/wrists pain due to Rheumatoid Arthritis (RA)?

Posted by antoniodoria @antoniodoria, Nov 23, 2025

I have been recently diagnosed with R.A. and would like to know if others, with same situation, have found effective treatments. Thank you.

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Profile picture for naturalcranberry @naturalcranberry

I was diagnosed with seronegative RA 3.5 years ago, and it primarily affects my hands. I’ve got two small kids, so I’ve chosen a pretty aggressive course of treatment to manage symptoms, maintain mobility, and prevent long term damage. It’s my understanding that beginning therapies sooner than later is ideal to keep your joints in good shape for as long as possible.

I initially was started on hydroxychloroquine, which I tolerated well and was effective at managing mild flares for about 2.5yrs. I utilized occasional rounds of prednisone for particularly stubborn flares, as well as cortisone injections for a couple unresponsive joints. I also saw an acupuncturist regularly (which I highly recommend), and deployed ibuprofen strategically.

I also started seeing hand OT, which was very useful - I strongly recommend getting set up with an OT who works specifically with hands and is knowledgeable about inflammatory arthritis because the exercises and management are different than for osteoarthritis. I’d suggest making “acute care”, “recovery”, and “management” plans with the hand therapist. I have an arsenal of splints, exercises, gadgets, and tricks they’ve given me that are all useful depending on the circumstance.

My RA has worsened somewhat in the last year, so I’ve changed up my meds but I still utilize cortisone injections as well as acupuncture, hydrotherapy, and compression gloves or sleeves for individual fingers or the whole hand. I also follow an anti inflammatory diet and try to be mindful about not pushing my hands too far. It’s all been an exercise in trial and error and it evolves over time - communicating any significant changes to your rheumatologist in a prompt fashion will help them create a good plan for you.

But really my best advice is to take a multifaceted approach to pain and symptom management - meds + PT/OT + alternative therapies + lifestyle modifications tailored to your specific needs is the way to go. Meds will help reduce or prevent flares/joint damage, while the rest will help support the joints and facilitate recovery over time. No amount of PT will prevent a flare for me personally, but knowing how to manage when I’m having one and how to regain mobility when one is over has helped enormously!

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@naturalcranberry Thank you so much for all of this information. It will be so helpful. I don’t have RA, or don’t think I do, but my hands and wrists have been hurting a lot the past couple of months. I really like your multifaceted approached to medications and treatments. Thank you again! Becky

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Profile picture for jimiwho @jimiwho

@phxbarb I am known to weap my wrists and hands in lidocaine patches. Helps some but along with paine in wrist I feel like hole in wrist, bones forearms feel broken andvthere are deposits of some sort between bones and on backs if my hands which and rheumatologust says is RA. Anyone else hear this ir do this? Dr mived too far away. Need new one who knows what to do.

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@jimiwho
Hi! I haven't answered a lot of people but you sounded like maybe I could help a little. I have RA and PsA and the good ole osteo. I use Vitality Essential Oils on my hands and arms. Frankicense is the best but I also use Helichrysum which is amazing for bruising, cuts, scrapes and in the summer the nasty fly bites. Theres others that I have not tried, but the reviews are amazing. Give it a try???

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I get infusions with simponi aria. It works. The pain subsides and I can move my joints. Do not let RA continue without treatment. It will damage your joints permanently. Taking nsaids is not enough. Eventually nsaids destroy your stomach lining . See a rheumatologist and get treatment to stop the damage.

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Profile picture for Sue, Volunteer Mentor @sueinmn

@bens1 Please keep us posted. We have a current discussion asking whether anyone has tried it. Since my RA is "dispersed" and affects more than one part of my body, I will ask my rheumatologist about it at my next appointment.
So far, it appears use will be limited to people who have failed both DMARD and Biologic drug treatments, so I probably won't qualify. But my daughter is on her third biologic, so she might qualify.

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@sueinmn
As of yesterday, Setpoint Medical has not released the secret list of those hospitals that are about to use it.

I stopped by the rheumatology dept at Mayo Fl 2 days ago and casually spoke to a wandering rheumatologist who said they were just talking about the device but that its use has to go through Mayo Minnesota first.

Here is a link to the Abstract and findings for the randomized trial from the Setpoint Medical web site:
https://setpointmedical.com/vagus-nerve-mediated-neuroimmune-modulation-for-rheumatoid-arthritis-a-pivotal-randomized-controlled-trial/

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I have RA with considerable joint damage. I use compression gloves and a wrist brace when I have to vacuum or take out trash, etc. I have cold gel gloves and microwave heating mitts. These all help tremendously.
CBD balm also helps.
I started on Low Dose Naltrexone last August because I had no results with methotrexate and Humira. and in three months, most of my pain, swelling and stiffness was gone. Even my shoes became loose due to the diminished swelling.

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I was in awful awful hand and wrist pain, prior to starting on Enbrel. I use the injections and it has been a miracle for me. Right now I am on a hold, since I had a rather bad infection the last 3 months. But I saw my RA yesterday and I will be resuming Enbrel within the next month. It looks like the infection has cleared (hopefully) so I will start out again, doing the injections every 2 weeks instead of 10 days, as prior. So far, pain is still gone but RA says it won't last without Enbrel. I have been off it for one month.

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