How Long For Body To "Reset"?

Posted by formisc @formisc, Jan 25 8:33pm

Hi, everyone! I am new to this forum and this is my first post although i have been reading through the various threads in the Osteoporosis group for a few weeks now and learnt a whole lot

Some background - I am in my mid-60s with no prior fragility fractures. I was diagnosed with osteoporosis with TScore of -2.7 for femur neck in mid-2022 and my doctor put me on Prolia which i (regrettably) accepted without any prior research. While on Prolia, i started reading up on the condition and the various meds. After my 3rd injection, it became clear to me that i should not have started on Prolia (which supposedly should only be prescribed if other less potent meds do not work). If anything, i read that the right sequence should have been to start with an anabolic and then follow it with an anti-resorptive. So when the time came for my 4th Prolia injection, i opted out and started on a weekly dose of Alendronate to mitigate against the dreaded rebound effect of Prolia. I have since taken 4 doses of Alendronate and other than a mild gastric and some pain near the side of my knee (which could also be due to overenthusiastic squats), it has been ok

My question is, how long will it be before my body can "reset" so that i can, if i decide to do so, commence taking an anabolic like Forteo or Tymlos from a clean slate without the disadvantages of having traces of Prolia or Alendronate still in me? Right now, it seems like a balancing act - i have to continue to take Alendronate to mitigate the rebound effect (for how long?) - but the more doses of Alendronate i take, the longer it will linger inside and affect the effectiveness of any anabolic med i take later

Any comments/insights are welcome. My prayers for everyone's good health and well being

Interested in more discussions like this? Go to the Osteoporosis & Bone Health Support Group.

@formisc

It's interesting that your mother suffered dry mouth from Alendronate. I already suffer this symptom from my Sjogren's but it seems like it has gotten much worse the past few weeks since i started on Alendronate. It does not seem to be on the list of side-effects

It seems that many people suffer side-effects from Alendronate and many have commented that it did not improve their bone density. But my reason for taking Alendronate is not really for increasing BMD but purely to mitigate the Prolia rebound effect. Hence i am not considering any other osteo med at this point in time

Once i am out of the Prolia rebound window (i believe it's 2 years), i will rethink my treatment options although i will be heavily leaning towards non-pharmacological treatments

Which is why the OsteoBoost Belt looks interesting. That and the Marodyne vibration plate although i prefer to see if there is more evidence supporting usage for osteoporosis before i commit to either one

Thank you for your research on Sjogren and Alendronate. In fact, one of the main reasons i want to quickly exit from Prolia and bisphosphonates in general is because Sjogren's makes me more prone to dental issues and ONJ is a big worry

It's interesting that you brought up the subject of tori which i have not heard of before. I do have a small bony lump at the roof of my mouth but my dentist had told me that it was not anything to worry about and that it was merely the remnant of a molar that had floated to that position - how it got there she never explained. Now i think it is more likely to be tori

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I understand why you are sticking with the alendronate. I'm guessing, due to the Sjogren, you already use something like Biotene to help with the dry mouth, but if you don't, you might want to consider it.

That's funny about the tori. Generally, the only people who've heard of tori are those who have tori that causes issues. You should mention to your dentist that you think that remnant molar in the roof of your mouth might be Torus Palatinus (Palatal Tori).

There are many of us in the low BMD world who want to know if vibration therapy actually works. I've searched and found a few testimonials claiming that LIV has increased bone density such as this one https://mybones.health/health-news/carols-story/ but that was from a website that sells the Marodyne LiV so....

I've watched interviews with Dr. Rubin, the scientist behind the Marodyne LiV, and he sounds pretty convincing, but $3000 is a lot to pay when you don't know whether or not it will improve your BMD. If I were 100% positive it would work for me, I'd pay $10,000+ for it 🙂

The good thing about the OsteoBoost Belt is that, if/when it becomes available, it will be covered by insurance.

I recently discovered Dr. Doug Lucas. He has a 3 part series on vibration therapy. In one of the sessions, he talks with Dr. Rubin about the Marodyne LiV. Here is a link to Dr. Lucas talking about whether or not vibration therapy works. Ultimately, it sounds like he thinks it might. https://www.youtube.com/watch?v=LVfn7r8ddTc

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@fearfracture

I understand why you are sticking with the alendronate. I'm guessing, due to the Sjogren, you already use something like Biotene to help with the dry mouth, but if you don't, you might want to consider it.

That's funny about the tori. Generally, the only people who've heard of tori are those who have tori that causes issues. You should mention to your dentist that you think that remnant molar in the roof of your mouth might be Torus Palatinus (Palatal Tori).

There are many of us in the low BMD world who want to know if vibration therapy actually works. I've searched and found a few testimonials claiming that LIV has increased bone density such as this one https://mybones.health/health-news/carols-story/ but that was from a website that sells the Marodyne LiV so....

I've watched interviews with Dr. Rubin, the scientist behind the Marodyne LiV, and he sounds pretty convincing, but $3000 is a lot to pay when you don't know whether or not it will improve your BMD. If I were 100% positive it would work for me, I'd pay $10,000+ for it 🙂

The good thing about the OsteoBoost Belt is that, if/when it becomes available, it will be covered by insurance.

I recently discovered Dr. Doug Lucas. He has a 3 part series on vibration therapy. In one of the sessions, he talks with Dr. Rubin about the Marodyne LiV. Here is a link to Dr. Lucas talking about whether or not vibration therapy works. Ultimately, it sounds like he thinks it might. https://www.youtube.com/watch?v=LVfn7r8ddTc

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No, i have not tried Biotene because prior to the past few weeks, my dry mouth had been manageable.
Coincidentally, my doctor just recommended the Oral 7 mouth gel but i think Biotene may be more effective. Seems like Biotene comes in various forms - mouth rinse, toothpaste, gel and even lozenges. Did your mother have preference for any particular form?

Yes, i'll be sure to surprise my dentist with my new-found knowledge on tori!

I will certainly keep an eye out for the OsteoBoost Belt - the good thing is that it won't take up much space and should also cost less than the Marodyne

I do subscribe to Dr Doug Lucas' youtube channel. I like that he puts osteo meds as a last resort rather than a first line of treatment

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@formisc

No, i have not tried Biotene because prior to the past few weeks, my dry mouth had been manageable.
Coincidentally, my doctor just recommended the Oral 7 mouth gel but i think Biotene may be more effective. Seems like Biotene comes in various forms - mouth rinse, toothpaste, gel and even lozenges. Did your mother have preference for any particular form?

Yes, i'll be sure to surprise my dentist with my new-found knowledge on tori!

I will certainly keep an eye out for the OsteoBoost Belt - the good thing is that it won't take up much space and should also cost less than the Marodyne

I do subscribe to Dr Doug Lucas' youtube channel. I like that he puts osteo meds as a last resort rather than a first line of treatment

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My mother used the Biotene mouth rinse a couple of times a day. I don’t think she has to use it anymore (since quitting alendronate). She also carried sugar-free mints in her pocket just in case.

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@formisc

No, i have not tried Biotene because prior to the past few weeks, my dry mouth had been manageable.
Coincidentally, my doctor just recommended the Oral 7 mouth gel but i think Biotene may be more effective. Seems like Biotene comes in various forms - mouth rinse, toothpaste, gel and even lozenges. Did your mother have preference for any particular form?

Yes, i'll be sure to surprise my dentist with my new-found knowledge on tori!

I will certainly keep an eye out for the OsteoBoost Belt - the good thing is that it won't take up much space and should also cost less than the Marodyne

I do subscribe to Dr Doug Lucas' youtube channel. I like that he puts osteo meds as a last resort rather than a first line of treatment

Jump to this post

A search here in this forum will show other threads discussing both the Marodyne and OsteoBoost. The latest is that early word from the not yet published VIBMOR trial in Australia is disappointing. Little or no benefit shown for the Marodyne. Hopefully the study will be published soon and what we know about vibration for osteoporosis will become more clear.

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@fearfracture

My mother used the Biotene mouth rinse a couple of times a day. I don’t think she has to use it anymore (since quitting alendronate). She also carried sugar-free mints in her pocket just in case.

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Thank you. I will give the mouth rinse a try

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I found this by accident. It addresses starting Evenity after Forteo but it is behind a paywall.

https://www.themednet.org/how-do-you-time-evenity-after-completion-of-forteo
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