How is it that a person can be allergic to insulin when your body prod

Have you consulted with an endocrinologist?

Hi,
I'm T2 and having problems with insulin reactions after reacting to every available pill. I came across a similar case at diabetesdaily.com while searching for answers. It reads;
I'm type 1, diagnosed in july 2004.
I've spent the last 18 months feeling unwell,
Palpitations, unable to concentrate, tired, balance is off, dizziness, and just a general sense of being unwell.
After countless visits to my endocrinologist, GP, diabetes nurse, I kept complaining to them all that I was not feeling well, I was testing myself 10-12 times a day just to make sure that the symptoms I was experiencing were not associated with low blood sugar levels or high levels. After ruling out my sugar levels, I started looking at other possibilities.
I had countless blood tests and all came back normal, HbA1c measured every 3 months was always in the normal range: 6.9, 7.3, 6.5. No Thyroid problems showed up, and all things that can be measured came back normal. It got to the point were my Endo ran out of ideas! I then went to the heart specialist and all tests came out normal, I had a heart ultrasound, 24 hour monitor, tilt table test, no problems with the heart! My endo then decided to sent me to the psychiatrist, I meet the psychiatrist and he told me he could not find the cause for my symptoms (no signs of hyperventilation or Panic attack), I live a normal life, work a 9till5 job and am married to a loving wife and have a healthy 1 1\2 year old daughter.

So here is the bit of good news I wanted to share!

It was by mistake that I did not inject my nightly injection of long acting Insulin (Protaphane), and the next day I felt absolutely fine, wow, what a difference, so i rang my endo immediately and told him that I felt fine! and asked him if it could be the long acting insulin that was giving me this sickening side effects. He thought I was wrong to think that it could be the long acting insulin because all the countless number of patients he has seen, none have reported this symptoms/ side effects.

So I stayed off the long acting insulin for a further 2 weeks, and just used the Novorapid every 3 hours, and continued to feel absolutelly fine!

My endo then had me try different types of long acting insulins, I tried Glargine/Lantus, Protaphane/Humulin N, Detemir/Levemir and the side effects came back with all of them!
The worst I've felt was when I was injecting 16 units of Protaphane every night.

I then researched the long acting insulins over the net and came across the excipients used in long acting insulins. It is plausible to think that I am allergic to one of the excipients.

I contacted my endo again and asked if he could contact the company that manufactures the long acting insulins in order to find out the exact content of my medication. One company has written back to him and this is what they came back with:
HUMULIN NPH and HUMULIN 30/70
Each vial or cartridge will contain human insulin (recombinant DNA origin) and the following excipients:
m-cresol distilled 1.6 mg/mL,
glycerol,
phenol 0.65 mg/mL,
protamine sulphate,
dibasic sodium phosphate,
zinc oxide,
water for injections.
Hydrochloric acid and/or sodium hydroxide may have been used during manufacture.

Obviously we are not all the same, I hope I am not going down this pathway but have crossed of Lantus thus far now starting a trial of Pantaphane.
Cheers

Hi,
Interestingly I seem to be going down the same pathway of reactions to insulin. Just had to stop Protaphane as the side effects have become unsustainable, with similar reactions to what I experienced from Lanus.
Cheers