How important is molecular response (allele burden) for pv treatment?

I have had pv for about 2 1/2 years. Last time my Jak2 was tested it went up a few points.
It was 77.
My hematologist was a little concerned about this and mentioned 2 strategies that have been shown to more rapidly reduce the allele burden for some people:
One is rapid titration of Besremi 250-350-500 in a few weeks and the other is combining Besremi and Jakafi. I am currently taking 300 mcg of Besremi and my hematocrit is 36 and my platelets are 118. I am feeling fine now. Is it worth sacrificing a little quality of life for a short time to try to get the allele burden down?