I wonder this too. I am also concerned about the timing of Reclast after Evenity, similar to the concern about timing after Prolia. Evenity has a long half life of 12+ days so it hangs around for awhile. Is Reclast not effective while there is still Evenity in the system? On the other hand, is there bone loss if we wait too long?
Rebound means quick loss of bone density and increased fracture risk when stopping a drug like Prolia. In fact, if Prolia is stopped without a follow-up drug (Reclast) things may even be worse than when Prolia was started, according to "Great Bones."
I wonder this too. I am also concerned about the timing of Reclast after Evenity, similar to the concern about timing after Prolia. Evenity has a long half life of 12+ days so it hangs around for awhile. Is Reclast not effective while there is still Evenity in the system? On the other hand, is there bone loss if we wait too long?
My thoughts exactly!!
Where are we able to get real answers to those questions? I need to figure that out in the next 2 months as my 12th Evenity shots are on March 7th.
My thoughts exactly!!
Where are we able to get real answers to those questions? I need to figure that out in the next 2 months as my 12th Evenity shots are on March 7th.
@mao22 I'll post if I find out anything on this and let me know if you do! Evenity is so new, there is little data. Even McCormick doesn't cover this in "Great Bones." I'll be asking him next week, and my doc. I have an additional concern because due to kidney disease, Evenity may hang around even longer for me.
So far it is known that the bone gains with Evenity are lost if not followed up with another med (anti-resorptive) to keep those gains from disappearing. So they have I presume measured this bone loss. This happens for Forteo and Tymlos also. Prolia can cause something beyond that. You don't just lose what you gained you may become extremely fracture prone. Some have multiple fractures in a short period of time. Very scary.
This has so far not been reported with Forteo, Tymlos, or Evenity. It's best not to mix up bone loss after stopping an anabolic medication with the possible extreme fracture rate that sometimes happens with Prolia. Maybe the phrase rebound effect should be reserved for Prolia. Though in my mind "rebound effect" is not a strong enough warning for what could happen after stopping Prolia.
So far it is known that the bone gains with Evenity are lost if not followed up with another med (anti-resorptive) to keep those gains from disappearing. So they have I presume measured this bone loss. This happens for Forteo and Tymlos also. Prolia can cause something beyond that. You don't just lose what you gained you may become extremely fracture prone. Some have multiple fractures in a short period of time. Very scary.
This has so far not been reported with Forteo, Tymlos, or Evenity. It's best not to mix up bone loss after stopping an anabolic medication with the possible extreme fracture rate that sometimes happens with Prolia. Maybe the phrase rebound effect should be reserved for Prolia. Though in my mind "rebound effect" is not a strong enough warning for what could happen after stopping Prolia.
proliamistake, I have given up on my doctors understanding these drugs or learning more about them. I believe that ALL of their knowledge of the drugs comes from drug reps and maybe attending a pharmaceutical convention.
At the endocrinology convention, the pharmaceutical companies have lavish exhibits designed to seduce doctors.
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I wonder this too. I am also concerned about the timing of Reclast after Evenity, similar to the concern about timing after Prolia. Evenity has a long half life of 12+ days so it hangs around for awhile. Is Reclast not effective while there is still Evenity in the system? On the other hand, is there bone loss if we wait too long?
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1 ReactionCould you explain “rebound issues”?
Rebound means quick loss of bone density and increased fracture risk when stopping a drug like Prolia. In fact, if Prolia is stopped without a follow-up drug (Reclast) things may even be worse than when Prolia was started, according to "Great Bones."
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1 ReactionMy thoughts exactly!!
Where are we able to get real answers to those questions? I need to figure that out in the next 2 months as my 12th Evenity shots are on March 7th.
@mao22 I'll post if I find out anything on this and let me know if you do! Evenity is so new, there is little data. Even McCormick doesn't cover this in "Great Bones." I'll be asking him next week, and my doc. I have an additional concern because due to kidney disease, Evenity may hang around even longer for me.
-
Like -
Helpful -
Hug
2 ReactionsSo far it is known that the bone gains with Evenity are lost if not followed up with another med (anti-resorptive) to keep those gains from disappearing. So they have I presume measured this bone loss. This happens for Forteo and Tymlos also. Prolia can cause something beyond that. You don't just lose what you gained you may become extremely fracture prone. Some have multiple fractures in a short period of time. Very scary.
This has so far not been reported with Forteo, Tymlos, or Evenity. It's best not to mix up bone loss after stopping an anabolic medication with the possible extreme fracture rate that sometimes happens with Prolia. Maybe the phrase rebound effect should be reserved for Prolia. Though in my mind "rebound effect" is not a strong enough warning for what could happen after stopping Prolia.
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4 Reactionswe don't that has been my complaint from day one we are given drugs the drs really know very little about and really don't seem to want to know
Not sure enough is known about Evenity yet. My doc says "no date yet" frequently.
Maybe we could call it “system collapse “.
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1 Reactionproliamistake, I have given up on my doctors understanding these drugs or learning more about them. I believe that ALL of their knowledge of the drugs comes from drug reps and maybe attending a pharmaceutical convention.
At the endocrinology convention, the pharmaceutical companies have lavish exhibits designed to seduce doctors.
-
Like -
Helpful -
Hug
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