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Hormone Replacement Therapy for Anxiety

Posted by meingan @meingan, Nov 16, 2025

Please share if you have experience with Transdermal HRT to treat anxiety. Mainstream medical science seems to believe that a women’s hormones stabilize after menopause. I’m 67 and have gone thru 15 years of hot flashes, suddenly they stopped and coincidentally? I came down with both widespread dermatitis and very severe anxiety disorder. I have started transdermal HRT and praying that this is the source of my debilitating conditions so that I don’t have to rely on antidepressants long term.

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lsammartino | @lsammartino | 3 days ago

Ooh, I feel like my anxiety is off the charts this year. I’m 57 and in full menopause for a few years. Hot flashes still. Became single sided deaf in 2020 from a virus and I know this has also affected my cognitive processing, mood, ability to filter, focus and prioritize. One Dr suggested ADHD meds for me early on but I resisted. I’m ready to re-consider because the irritability and anger has become so bad. Just tried 200 mg of oral progesterone the last 3 nights in a row and already I have side effects. Constipation. Rectal pain and pressure. Dizziness. So I’m going to stop that cold turkey. A friend suggested Ona’s topical bio identical progesterone cream. I’m just so confused about what route for me to proceed with. Thanks for sharing your story too.

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meingan | @meingan | 3 days ago
In reply to @lsammartino "Ooh, I feel like my anxiety is off the charts this year. I’m 57 and in..." + (show)
Profile picture for lsammartino @lsammartino

Ooh, I feel like my anxiety is off the charts this year. I’m 57 and in full menopause for a few years. Hot flashes still. Became single sided deaf in 2020 from a virus and I know this has also affected my cognitive processing, mood, ability to filter, focus and prioritize. One Dr suggested ADHD meds for me early on but I resisted. I’m ready to re-consider because the irritability and anger has become so bad. Just tried 200 mg of oral progesterone the last 3 nights in a row and already I have side effects. Constipation. Rectal pain and pressure. Dizziness. So I’m going to stop that cold turkey. A friend suggested Ona’s topical bio identical progesterone cream. I’m just so confused about what route for me to proceed with. Thanks for sharing your story too.

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@lsammartino That’s a pretty high dose of progesterone. I’m using cream, 40mg progesterone and 0.625mg estrogen. Haven’t had any side effects. Been on for 2 months but I can’t really tell if it’s helped or not. I am less anxious but I’m also on a SNRI.

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lsammartino | @lsammartino | 3 days ago
In reply to @meingan "@lsammartino That’s a pretty high dose of progesterone. I’m using cream, 40mg progesterone and 0.625mg estrogen...." + (show)
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@lsammartino That’s a pretty high dose of progesterone. I’m using cream, 40mg progesterone and 0.625mg estrogen. Haven’t had any side effects. Been on for 2 months but I can’t really tell if it’s helped or not. I am less anxious but I’m also on a SNRI.

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@meingan would you believe with the Ona’s topical cream they recommend you start with 400 mg a day split over several doses? Eeeeks. I might just be desperate enough to try as I’m waiting to see my neuro dr about possible antidepressants but that’s not till end of January. Ugh. I hate this trial and error-hurry up and wait process. Glad you’re getting results personally. Hope it keeps up.

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blueskies1530 | @blueskies1530 | 2 days ago
In reply to @lsammartino "Ooh, I feel like my anxiety is off the charts this year. I’m 57 and in..." + (show)
Profile picture for lsammartino @lsammartino

Ooh, I feel like my anxiety is off the charts this year. I’m 57 and in full menopause for a few years. Hot flashes still. Became single sided deaf in 2020 from a virus and I know this has also affected my cognitive processing, mood, ability to filter, focus and prioritize. One Dr suggested ADHD meds for me early on but I resisted. I’m ready to re-consider because the irritability and anger has become so bad. Just tried 200 mg of oral progesterone the last 3 nights in a row and already I have side effects. Constipation. Rectal pain and pressure. Dizziness. So I’m going to stop that cold turkey. A friend suggested Ona’s topical bio identical progesterone cream. I’m just so confused about what route for me to proceed with. Thanks for sharing your story too.

Jump to this post

@lsammartino Why such a high dose of Progesterone? It can be compounded down to 50mg either immediate or extended release.
I hope the cream helps you and please do share again if that brand helps.

I caught a virus in my left ear last year and almost lost my hearing in that ear. Fortunately, my ENT gave me a course of a virus med and put me to sleep and gave me a steroid shot in my middle ear. Over the course of a few months most of my hearing came back. It was one of the herpes viruses, maybe shingles and we stopped it before I caught developed the rash. It had spread into my left eye.

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