What to expect with EVP (Enfortumab Vedotin and Pembrolizumab)?

@katiw my 12 months of keytruda and Padcev rendered the classic side effects others have described. All subsided except neuropathy and after 1 year off still mild neuropathy. I over reacted to keytruda with rhinitis, pneumonitis and now constant cystitis, but in complete remission of cancer. Working on the cystitis and last resort would be bladder removal.due to symptoms and lifestyle limitations of urgency. The cancer treatment combo is a lifesaver if you can tolerate the side effects. Have faith as we have all been thru what you describe.. BTW, my hair came back thicker than before treatment.

@katiw, chemo brain is so hard. How many more cycles of EVP (enfortumab vedotin and pembrolizumab) do you have left?

@colleenyoung hi! I have three left! I think the mental part is so hard right now! After being in fight mode for a year, it’s hard to adjust to this new “normal” are you still on it?

@katiw

I developed pneumonitis from the Keytruda and had to drop that from the regimen.. I still will continue the others till 1 month of surgery.

@davemilisa oh no!! My eyes water soooo much and my nose runs constantly, good luck on your surgery!!

I did nivo 2025-04 - 2026-03. I have had many side effects. Liver/Lung/Kidney/Sinus inflammation, rashes/itching, trouble walking, low electrolytes, thyroid is failing, eosinophilia. I learned to deal with it. Better than the alternative. Nivo is the twin of Pembro,

There are padcev only patients on Reddit and BCAN Inspire that have done padcev for up to 6 years straight. Dosage reductions and temporary breaks help them a lot. But it is a very toxic treatment.

Another promising next salvage treatment is TROP2. One trial for one product failed. The other trial for another product succeeded. See: https://www.urotoday.com/clinical-trials/from-the-editor/153195-is-trop2-just-not-what-we-thought-it-was-for-bladder-cancer-where-to-go-after-tropics-04.html.