Has anyone had their tumor/lesion SEQUENCED in addition to biopsy?

Hi, Michzn,
I had a the genomics of a cancerous tumor sequenced ten years ago. None of the oncologists I was seeing were interested, but the results I received from the testing company saved me from a triplet of chemotherapeutic medications with troubling side effects. I received a sheet of mutations, accompanied by a list of meds that had failed against the tumor's mutations There were possible medication, one in a clinical trial that had already closed. The research base of the medications were included as well as the most likely sites for mutation of each misfolded gene. I would recommend that every biopsied tumor be tested.
The company was Foundation1. I had to travel around the country to find an oncologist who would treat the cancer without chemotherapy.

This is common now with NCI clinics. Natera Altera, Tempus and so on. It informs risk (TP53 for example), likelihood of ICI response (TERT for example) and so on.

However, for MIBC, the impact is limited as treatment remains limited: chemo, ICI and EVP. Plus some niche treatments and clinical trials.

HER2 is a key consideration. As is NECTIN4 (rarely checked). PD(L)1 is key for determining likelihood of ICI response (mostly used in EU and CA: US is all-comer typically).

@jaxfl Thank you, extremely helpful. I finally got someone within the CC to coordinate the test. Literally no one knew what I was asking for - it was so frustrating, to say the least. They are telling me the test completion takes about 3 weeks.

@michzn, tumor sequencing and genomics is an active area of treatment and research for more individualized treatment for cancer patients. Here's some research and information from Mayo Clinic

Asher Chanan-Khan, M.D., Chair of Hematology and Oncology and the Director of Individualized Medicine Clinic at Mayo Clinic in Florida discusses the sequencing of the human genome and how it can be used to treat cancer patients.