Has anyone experienced sensitive teeth while taking Hydroxyurea ?

On 1000 mg of HU a day for more than a year, I have not experienced this.

But we are all different! Hope others will chime in with helpful suggestions.

Yes. I have bleeding gums which I get periodically treatment for. But now teeth occasionally have pain. Usually in one or two. The bleeding gums is partly related to dry mouth, I think. I also have dry eyes and dryness in other mucous membranes. I think it is related to ET not treatment because I had these symptoms before I started treatment.

On 500mg Hydroxyurea a day for 8 months. I experienced pain in my teeth initially for a few days but it went away. I sometimes have a problem with mouth sores but found a predental rinse that helps.

I was diagnosed with PV in Dec 2025 and have been on HU since late December. I noticed the same thing, even before I was diagnosed. My teeth seem sensitive and sometimes blood with brushing/flossing. I have flossed for years and never had any gum issues after I started flossing. So I think it might be the PV itself. Not sure. Have doc appt tomorrow and plan to ask about this.

Hello I'm in the UK, I'm currently on one 1000mg per day of Hydrea and have been on this medication since around 2019. I don't have any issues with my teeth. I have started having issues with hair loss and brittle nails.
I'm male and 70 years old though.

Yes!!! When they switched me to seven days a week I couldn’t tolerate it. I had such tooth sensitivity and nerve pain. Not hot or cold sensitivity just random tooth pain that comes and goes. I switched back to five days and have phlebotomies more often instead of increasing meds. I have PV diagnosed three years ago.

@sylann725 Correction to my previous post, I use a pre-brush dental rinse that helps the mouth sores.

@eloise999 thank you for replying!!