1. < Epilepsy & Seizures

Has anyone DAO (diamine oxidase) deficiency?

Posted by Chris Gautier OR Santosha @santosha, Jan 7 7:08pm

Hi All,
Recently, my gastroenterologist has asked me to take an exam to evaluate my DAO levels and I see I have a certain deficiency. Researching more about it on the internet, I have learned that DAO deficiency is mostly genetic, but can also be caused by medications such as anti-depressants, AEDs (especially carbamazepine, phenobarbital and valproate) and others.
Though it seems that the relationship between Diamine Oxidase (DAO) and epilepsy has not yet been extensively documented, there are some pieces of evidence that abnormal DAO levels can influence seizure activity.
Has anyone here in the group done this exam to measure his or her DAO levels? Curious to know.
Thank you!
Chris (@santosha)

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Chris Gautier OR Santosha | @santosha | 8 hours ago

@lisalucier
Hi Lisa, Good Morning
Do you know of any article or study by the Mayo Clinic regarding the relationship between histamine/ DAO Deficiency and seizures? And also what are the AEDs that can cause DAO deficiency?
Here I share a study from 2012 that I have found through searching more about this subject.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3514756/#:~:text=Histamine%20is%20considered%20to%20be,et%20al.%2C%202004)
Yesterday, I was at my gastro and came out of this appointment with her very disappointed. She said I am not a specialist in epilepsy and AEDs. Initially, she said she was not aware that AED could cause DAO deficiency, but after making quick searches she found that carbamazepine and topiramate can cause DAO deficiency. Clearly, she did not prepare for this appointment.
She said that Keppra can cause all those gastrointestinal problems I am having and recommended I see a nutritionist to start a diet to hold on better with Keppra and feel a bit better.
Thank you!
Chris (@santosha)

REPLY
1 reply
Moderator
Lisa Lucier, Moderator | @lisalucier | 2 hours ago
In reply to @santosha "@lisalucier Hi Lisa, Good Morning Do you know of any article or study by the Mayo..." + (show)
@santosha

@lisalucier
Hi Lisa, Good Morning
Do you know of any article or study by the Mayo Clinic regarding the relationship between histamine/ DAO Deficiency and seizures? And also what are the AEDs that can cause DAO deficiency?
Here I share a study from 2012 that I have found through searching more about this subject.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3514756/#:~:text=Histamine%20is%20considered%20to%20be,et%20al.%2C%202004)
Yesterday, I was at my gastro and came out of this appointment with her very disappointed. She said I am not a specialist in epilepsy and AEDs. Initially, she said she was not aware that AED could cause DAO deficiency, but after making quick searches she found that carbamazepine and topiramate can cause DAO deficiency. Clearly, she did not prepare for this appointment.
She said that Keppra can cause all those gastrointestinal problems I am having and recommended I see a nutritionist to start a diet to hold on better with Keppra and feel a bit better.
Thank you!
Chris (@santosha)

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Hi, @santosha - I don't off the top of my head, but I can look into it.

Sorry to hear about the disappointing appointment.

REPLY
Chris Gautier OR Santosha | @santosha | 52 minutes ago

@lisalucier
Hi Lisa, thank you so much. I would appreciate much your looking at Mayo Clinic to see if there are any studies or articles related to this subject.
Chris (@santosha)

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