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Anyone experience GI side effects with Tagrisso for lung cancer?

Posted by sunnygirl @sunnygirl, Mar 28, 2022

Hello,
Has anyone out there receiving Tagrisso for their lung cancer treatment experienced GI problems? For example bloating 24/7, appetite loss, heart rate elevated when eating, stomach pain. My husband is experiencing all of these after being on Tag for six months. Not sure if it warrants a visit to the ER. Currently have a message into his oncologist.

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Lyran | @privatenurse | Apr 29, 2023
In reply to @privatenurse "Interaction between Tagrisso and Zofran -major Using osimertinib together with ondansetron can increase the risk of..." + (show)
@privatenurse

Interaction between Tagrisso and Zofran -major
Using osimertinib together with ondansetron can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening.

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A cup of peppermint tea with a tea ball filled with fennel seeds works well for nausea. A registered dietician at a cancer institute told me years ago. Try it.

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dik27 | @dik27 | Apr 30, 2023

Yes I am having a terrible time diarrhea right after I eat. Its frustrating sometimes don't make it to bathroom. also have in digestion. I had IBD before the diagnosis of cancer. have been keeping food diary and bathroom diary. Dairy products seem to be a big issue. but sometimes there is no reason for it.Take a lot of immodium. going to be discussing with doctor next appointment

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Lisa, Volunteer Mentor | @lls8000 | May 1, 2023
In reply to @dik27 "Yes I am having a terrible time diarrhea right after I eat. Its frustrating sometimes don't..." + (show)
@dik27

Yes I am having a terrible time diarrhea right after I eat. Its frustrating sometimes don't make it to bathroom. also have in digestion. I had IBD before the diagnosis of cancer. have been keeping food diary and bathroom diary. Dairy products seem to be a big issue. but sometimes there is no reason for it.Take a lot of immodium. going to be discussing with doctor next appointment

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Hi @dik27, these drugs can really be tough on the delicate GI balance, especially when you have IBD too. I'm glad you are talking with your doctor, they may have some suggestions.
I take a different targeted therapy, I don't have your additional complication of IBD, but especially in the beginning I struggled with GI issues. After the first 6 months or so the issues did improve. I saw a nutritionist to help with suggestions for getting additional fiber into my diet. I found that to be helpful. Have you had a consult with a nutritionist, or are you open to that?

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